Autophagosome biogenesis and human health.

Cell Discovery
Tsuyoshi Kawabata, Tamotsu Yoshimori

Abstract

Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides providing energy and building blocks during starvation via random degradation, autophagy selectively targets cytotoxic components to prevent a wide range of diseases. This preventive activity of autophagy is supported by many studies using animal models and reports identifying several mutations in autophagy-related genes that are associated with human genetic disorders, which have been published in the past decade. Here, we summarize the molecular mechanisms of autophagosome biogenesis involving the proteins responsible for these genetic disorders, demonstrating a role for autophagy in human health. These findings will help elucidate the underlying mechanisms of autophagy-related diseases and develop future medications.

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Citations

Jun 24, 2020·Cell Research·Li Yu
Aug 14, 2020·International Journal of Molecular Sciences·Daiki MuraseTamotsu Yoshimori
Nov 6, 2020·International Journal of Molecular Sciences·Isaac Tamargo-GómezGuillermo Mariño
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Santosh Phuyal, Francesco Baschieri
Nov 1, 2020·Journal of Cell Science·Noor Gammoh
Feb 9, 2021·Trends in Cell Biology·Siamak Redhai, Michael Boutros
Mar 7, 2021·Cells·Camille Sena-Dos-SantosGiovanna C Cavalcante
Apr 4, 2021·Cells·Georgios Konstantinidis, Nektarios Tavernarakis
Nov 8, 2020·Archives of Biochemistry and Biophysics·Tayana Mazin TsuboneMauricio S Baptista
Nov 28, 2020·Pharmacology & Therapeutics·Michele AventaggiatoMarco Tafani

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Methods Mentioned

BETA
GTPase
fluorescence microscopy
gene knockout
lipidation
exome

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An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

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Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

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