journal cover

Autophagy: a lysosomal degradation pathway with a central role in health and disease

Biochimica Et Biophysica Acta

Aug 19, 2008

Eeva-Liisa Eskelinen, Paul Saftig

Abstract

Autophagy delivers cytoplasmic material and organelles to lysosomes for degradation. The formation of autophagosomes is controlled by a specific set of autophagy genes called atg genes. The magnitude of autophagosome formation is tightly regulated by intracellular and extracellular amin...read more

Mentioned in this Paper

Receptors, Amino Acid
Establishment and Maintenance of Localization
Pathogenic Aspects
Biochemical Pathway
Biological Adaptation to Stress
Autophagic Vacuole Maturation
Calcium [EPC]
Conjugation
T-Lymphocyte
Tumor Suppressor Genes
38
502
Paper Details
References
  • References131
  • Citations249
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  • References131
  • Citations249
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Autophagy: a lysosomal degradation pathway with a central role in health and disease

Biochimica Et Biophysica Acta

Aug 19, 2008

Eeva-Liisa Eskelinen, Paul Saftig

PMID: 18706940

DOI: 10.1016/j.bbamcr.2008.07.014

Abstract

Autophagy delivers cytoplasmic material and organelles to lysosomes for degradation. The formation of autophagosomes is controlled by a specific set of autophagy genes called atg genes. The magnitude of autophagosome formation is tightly regulated by intracellular and extracellular amin...read more

Mentioned in this Paper

Receptors, Amino Acid
Establishment and Maintenance of Localization
Pathogenic Aspects
Biochemical Pathway
Biological Adaptation to Stress
Autophagic Vacuole Maturation
Calcium [EPC]
Conjugation
T-Lymphocyte
Tumor Suppressor Genes
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Biochimie

Regulation of macroautophagy by mTOR and Beclin 1 complexes

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New insights into the mechanisms of macroautophagy in mammalian cells

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Paper Details
References
  • References131
  • Citations249
12345...
  • References131
  • Citations249
12345...
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