Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option

Journal of Autoimmunity
Srinivasa Reddy BonamSylviane Muller

Abstract

Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel strategies that are under development, tools that modulate the immune system to restore normal tolerance mechanisms are central. In these approaches, peptide therapeutics constitute a class of agents that display many physicochemical advantages. Within this class of potent drugs, the phosphopeptide P140 is very promising for treating patients with lupus, and likely also patients with other chronic inflammatory diseases. We discovered that P140 targets autophagy, a finely orchestrated catabolic process, involved in the regulation of inflammation and in the biology of immune cells. In vitro, P140 acts directly on a particular form of autophagy called chaperone-mediated autophagy, which seems to be hyperactivated in certain subsets of lymphocytes in lupus and in other autoinflammatory settings. In lupus, the "correcting" effect of P140 on autophagy results in a weaker signaling of autoreactive T cells, leading to a signi...Continue Reading

Citations

Sep 4, 2019·Nature Reviews. Drug Discovery·Srinivasa Reddy BonamSylviane Muller
Dec 25, 2019·Journal of Immunology Research·Fangyuan YangErwei Sun
Jul 14, 2020·Frontiers in Immunology·Serena ColafrancescoRoberta Priori
Oct 7, 2020·Children·Fu-Chen HuangSung-Chou Li
Oct 28, 2020·International Journal of Molecular Sciences·Stefania CoccoMichelino De Laurentiis
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Xiang WangZhicheng Gong
Mar 26, 2021·Journal of Medicinal Chemistry·Junping PeiLiang Ouyang
Apr 4, 2021·International Journal of Molecular Sciences·Ana P PintoAdelino S R da Silva
Apr 7, 2019·Trends in Molecular Medicine·Sruthi Vijaya Retnakumar, Sylviane Muller
May 1, 2021·International Journal of Molecular Sciences·Ji-Hee NamDae-Seog Lim
Jul 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Niranjan G KotlaAbhay Pandit
Sep 30, 2021·Natural Products and Bioprospecting·Christian Bailly, Gérard Vergoten
Nov 27, 2021·The FEBS Journal·Swati ChauhanSantosh Chauhan

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