Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected

Brain Plasticity
Jagroop DhaliwalDiane C Lagace

Abstract

Within the brain, the physiological and pathological functions of autophagy in development and throughout the lifespan are being elucidated. This review summarizes recent in vitro and in vivo results that are defining the role of autophagy-related genes during the process of adult neurogenesis. We also discuss the need for future experiments to determine the molecular mechanism and functional significance of autophagy in the different neural stem cell populations and throughout the stages of adult neurogenesis.

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Citations

Mar 31, 2019·The FEBS Journal·Deepika Puri, Deepa Subramanyam
Apr 2, 2020·Frontiers in Cellular Neuroscience·Anna FassioFabio Benfenati
Oct 24, 2018·Frontiers in Cellular Neuroscience·Lucía Casares-CrespoHelena Mira
Oct 30, 2021·Omics : a Journal of Integrative Biology·Oishi ChatterjeeThottethodi Subrahmanya Keshava Prasad
Dec 19, 2021·Cell & Bioscience·Zhiqiang DengZhenyu Yue

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Methods Mentioned

BETA
transgenic
lipidation
fluorescence assay
or
gene knockout
dissection
single-cell sequencing

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