Autophagy and Autoimmune Diseases

Advances in Experimental Medicine and Biology
Min Jin, Yanyun Zhang

Abstract

Alterations of autophagy contribute to the progression of various autoimmune diseases, including systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and systemic sclerosis (SSc). In patients with SLE, autophagy defects result in poor clearance of phagocytic fragments and excessive secretion of inflammatory factors. The disorder of autophagy in IBD patients is closely related to the regulation of inflammatory factors and the clearance of pathogenic pathogens of enteropathy. The increase of autophagy in synovioblasts of RA patients will promote RA-associated synovitis. The autophagy of fibroblasts in SSc patients is dysfunctional, leading to overactive wound healing. Understanding the role of autophagy in the pathogenesis may give us hints on the therapy of autoimmune diseases.

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Nature Reviews. Rheumatology
Jason S Rockel, Mohit Kapoor
International Journal of Molecular Sciences
Efthymia Theofani, Georgina Xanthou
Sheng li ke xue jin zhan [Progress in physiology]
Tao HeYu-Zhen Tan
Journal of Alzheimer's Disease : JAD
Aaron Barnett, Gregory J Brewer
© 2021 Meta ULC. All rights reserved