Autophagy and cell death

Autophagy
Simone Fulda

Abstract

Autophagy exerts dual functions in cancer, acting as both a tumor suppressor, for example, by preventing the accumulation of damaged proteins and organelles, and as a tumor promoter that supports tumor growth. Many anticancer therapies engage autophagy as part of a cellular response. However, the question of whether or not autophagic activity in cells undergoing cell death is the cause of death or whether it is actually an attempt to support survival in response to cellular stress conditions has been discussed with great controversy.

Citations

Mar 29, 2014·Metallomics : Integrated Biometal Science·Cai-Ping TanZong-Wan Mao
Dec 21, 2012·Expert Opinion on Therapeutic Targets·Simone Fulda
Sep 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Man WuHongxi Xu
Jul 17, 2014·Oxidative Medicine and Cellular Longevity·Zhengtang QiShuzhe Ding
May 18, 2016·Chemico-biological Interactions·Lili ZhangWenyuan Gao
Jul 10, 2016·Methods : a Companion to Methods in Enzymology·Ivan A Vorobjev, Natasha S Barteneva
Jan 1, 2012·Cells·Ana BrennandPaul A M Michels
Dec 8, 2016·Journal of Biomedical Science·Najmeh RahmanianAli Khalaj

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