Autophagy and GLUT4: The missing pieces

Diabetes & Metabolic Syndrome
Safa Abdelgadir Mohamed ElhassanSubrat Kumar Bhattamisra

Abstract

Autophagy is a process devoted to degrade and recycle cellular components inside mammalian cells through lysosomal system. It plays a main function in the pathophysiology of several diseases. In type 2 diabetes, works demonstrated the dual functions of autophagy in diabetes biology. Studies had approved the role of autophagy in promoting different routes for movement of integral membrane proteins to the plasma membrane. But its role in regulation of GLUT4 trafficking has not been widely observed. In normal conditions, insulin promotes GLUT4 translocation from intracellular membrane compartments to the plasma membrane, while in type 2 diabetes defects occur in this translocation. Intriguing evidences discussed the contribution of different intracellular compartments in autophagy membrane formation. Furthermore, autophagy serves to mobilise membranes within cells, thereby promoting cytoplasmic components reorganisation. The intent of this review is to focus on the possibility of autophagy to act as a carrier for GLUT4 through regulating GLUT4 endocytosis, intracellular trafficking in different compartments, and translocation to cell membrane. The common themes of autophagy and GLUT4 have been highlighted. The review discussed the...Continue Reading

Citations

Dec 2, 2020·International Journal of Molecular Sciences·Jasminka GiacomettiSnježana Bajek
Aug 8, 2021·International Journal of Molecular Sciences·Vadim V KlimontovAnton I Korbut

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