Autophagy and liver cancer

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Yunus Akkoç, Devrim Gözüaçık

Abstract

Autophagy is a key biological phenomenon conserved from yeast to mammals. Under basal conditions, activation of autophagy leads to the protein degradation as well as damaged organelles for maintaining cellular homeostasis. Deregulation of autophagy has been identified as a key mechanism contributing to the pathogenesis and progression of several liver diseases, including hepatocellular carcinoma (HCC), one of the most common and mortal types of cancer. Currently used treatment strategies in patients with HCC result in variable success rates. Therefore, novel early diagnosis and treatment techniques should be developed. Manipulation of autophagy may improve responses of cancer cell to treatments and provide novel targeted therapy options for HCC. In this review, we summarized how our understanding of autophagy-cell death connection may have an impact on HCC therapy.

Citations

Sep 5, 2019·Viral Immunology·Asghar AbdoliAmitis Ramezani
Mar 4, 2020·Cancers·Chandramohan KiruthigaAnupam Bishayee
Oct 18, 2020·Particle and Fibre Toxicology·Xiaoli FengLongquan Shao
Apr 25, 2021·Molecular Biology Reports·Magdelyn Mei-Theng WongSin-Yeang Teow
May 13, 2021·International Journal of Hepatology·Suryakant NitureDeepak Kumar
Jun 3, 2021·Current Cancer Drug Targets·Negin Chaeichi-TehraniAmir Avan
Dec 19, 2021·Journal of Gastrointestinal Cancer·Yunus Akkoc, Devrim Gozuacik

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