Autophagy and mechanisms of effective immunity.

Frontiers in Immunology
Justine D Mintern, Jose A Villadangos

Abstract

Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, autophagy is a major pathway of degradation. It enables elimination of microbes that have invaded intracellular compartments. In addition, it promotes degradation of damaged cellular content, thereby acting to limit inflammatory signals. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including microbe elimination, inflammatory cytokine production, antigen processing and T and B lymphocyte immunity.

Citations

Aug 13, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tomi T KanninenSteven S Witkin
Aug 21, 2013·Immunological Reviews·Brieuc P PerotMatthew L Albert
Apr 17, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Abderrahman Chargui, Michèle Véronique El May
Sep 23, 2014·American Journal of Reproductive Immunology : AJRI·Bruna de Andrade RamosSteven S Witkin
Apr 16, 2013·Reproductive Sciences·Tomi T KanninenSteven S Witkin
Aug 23, 2017·Immunology and Cell Biology·Justine D Mintern, José A Villadangos
Nov 9, 2012·Protein & Cell·Natalie L Patterson, Justine D Mintern
Nov 14, 2020·Autophagy·Devanarayanan Siva Sankar, Jörn Dengjel

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Methods Mentioned

BETA
ubiquitination
transgenic
phosphotransferase
GTPase

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