Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity

The Journal of Physiology
Heather N CarterDavid A Hood

Abstract

A healthy mitochondrial pool is dependent on the removal of dysfunctional organelles via mitophagy, but little is known about how mitophagy is altered with ageing and chronic exercise. Chronic contractile activity (CCA) is a standardized exercise model that can elicit mitochondrial adaptations in both young and aged muscle, albeit to a lesser degree in the aged group. Assessment of mitophagy flux revealed enhanced targeting of mitochondria for degradation in aged muscle, in contrast to previous theories. Mitophagy flux was significantly reduced as an adaptation to CCA suggesting that an improvement in organelle quality reduces the need for mitochondrial turnover. CCA enhances lysosomal capacity and may ameliorate lysosomal dysfunction in aged muscle. Skeletal muscle exhibits deficits in mitochondrial quality with age. Central to the maintenance of a healthy mitochondrial pool is the removal of dysfunctional organelles via mitophagy. Little is known on how mitophagy is altered with ageing and chronic exercise. We assessed mitophagy flux using colchicine treatment in vivo following chronic contractile activity (CCA) of muscle in young and aged rats. CCA evoked mitochondrial biogenesis in young muscle, with an attenuated response ...Continue Reading

References

Sep 1, 1991·Medical & Biological Engineering & Computing·S Salmons, J C Jarvis
Mar 1, 1991·Journal of Medical Engineering & Technology·J C Jarvis, S Salmons
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
Mar 1, 1984·Mechanisms of Ageing and Development·B Wiederanders, B Oelke
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·O E RooyackersK S Nair
Jul 6, 2000·The Journal of Physiology·K E ConleyP C Esselman
Aug 24, 2000·Journal of Applied Physiology·J A Kent-Braun, A V Ng
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C T PutmanD Pette
Sep 16, 2006·Molecular Aspects of Medicine·Alexei TermanUlf T Brunk
Nov 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Peter J AdhihettyDavid A Hood
Jul 6, 2007·Autophagy·Noboru Mizushima, Tamotsu Yoshimori
Nov 22, 2007·Aging Cell·Béatrice ChabiDavid A Hood
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Oct 9, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Entela Bua LushajJudd M Aiken
Dec 25, 2008·Physiological Genomics·Ayesha SaleemDavid A Hood
May 15, 2009·American Journal of Physiology. Cell Physiology·Peter J AdhihettyDavid A Hood
Nov 12, 2009·Experimental Gerontology·Stephanie Eva WohlgemuthChristiaan Leeuwenburgh
Dec 1, 2009·Cell Metabolism·Eva MasieroMarco Sandri
Jan 2, 2010·Current Opinion in Cell Biology·Maria Chiara MaiuriGuido Kroemer
Jul 27, 2010·Autophagy·Jeong-Sun JuConrad C Weihl
Sep 3, 2011·Cell·David C RubinszteinGuido Kroemer
Jun 16, 2012·American Journal of Physiology. Cell Physiology·Heather N Carter, David A Hood
Dec 12, 2012·American Journal of Physiology. Cell Physiology·Michael F O'LearyDavid A Hood
Jan 19, 2013·The Journal of Biological Chemistry·Keir J MenziesDavid A Hood
May 8, 2013·Hypertension·Erika Yan WangLorrie A Kirshenbaum
Jul 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vitor A LiraZhen Yan
Aug 21, 2013·Autophagy·Mahroo MofarrahiSabah N A Hussain
Nov 5, 2013·Autophagy·James K ChingConrad C Weihl
Dec 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gilles GouspillouRussell T Hepple

❮ Previous
Next ❯

Citations

Jun 20, 2018·The Journal of Physiology·Anthony M J Sanchez
Nov 16, 2018·Acta Physiologica·Andrea Del Campo
Sep 15, 2018·Annual Review of Physiology·David A HoodMatthew Triolo
Oct 29, 2018·Pflügers Archiv : European journal of physiology·Yuho KimDavid A Hood
Mar 26, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Victoria L GremmingerCharlotte L Phillips
Nov 2, 2019·The Journal of Physiology·Jonathan M MemmeDavid A Hood
Apr 16, 2019·Exercise and Sport Sciences Reviews·Yuntian GuanZhen Yan
Mar 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alex P SeabrightYu-Chiang Lai
Jul 30, 2020·American Journal of Physiology. Cell Physiology·Sidney Abou SawanNathan Hodson
Jan 13, 2019·The Journal of General Physiology·Niklas IvarssonHåkan Westerblad
Dec 26, 2018·Expert Opinion on Therapeutic Targets·Anna PiccaEmanuele Marzetti
Dec 8, 2019·Nutrients·Ki Wung Chung, Hae Young Chung
Jan 5, 2020·Stem Cell Research & Therapy·Michalina AlickaKrzysztof Marycz
Jan 30, 2020·Cells·Alessandra StacchiottiLuigi Fabrizio Rodella
Jun 19, 2019·Oxidative Medicine and Cellular Longevity·Enza VernucciMatteo A Russo
May 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bjørg Thiellesen BuchHenriette Pilegaard
Nov 11, 2020·International Journal of Molecular Sciences·Manuela Bozzi, Francesca Sciandra
Dec 29, 2020·The Journal of Physiology·Ashleigh M PhilpAndrew Philp
Nov 26, 2019·Experimental Gerontology·Jiling LiangNing Chen
Dec 22, 2020·Frontiers in Physiology·Alex P Seabright, Yu-Chiang Lai
Dec 31, 2020·International Journal of Molecular Sciences·Vanina Romanello
Jan 10, 2021·Biology·Francesco BellantiGianluigi Vendemiale
Feb 16, 2021·Frontiers in Physiology·Jonathan M Memme, David A Hood
Mar 7, 2021·International Journal of Molecular Sciences·Anna S NichenkoJarrod A Call
Mar 16, 2021·Exercise and Sport Sciences Reviews·Ashley N OliveiraDavid A Hood
Apr 4, 2021·International Journal of Molecular Sciences·Ana P PintoAdelino S R da Silva
Apr 4, 2021·International Journal of Molecular Sciences·Robert SolsonaAnthony Mj Sanchez
May 1, 2021·International Journal of Molecular Sciences·Laura DobladoMaria Monsalve
Nov 14, 2020·International Journal of Molecular Sciences·Alisson L da RochaAdelino S R da Silva
Jun 1, 2021·Autophagy·Jason P ChuaSami J Barmada
Aug 8, 2021·International Journal of Molecular Sciences·Jean-Philippe Leduc-GaudetGilles Gouspillou
Aug 28, 2021·Cells·Xufeng CenHongguang Xia
Aug 28, 2021·International Journal of Molecular Sciences·Nicholas A ForemanLi Li Ji
Sep 4, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Matthew J LeesDaniel R Moore
Jun 12, 2021·Medicine and Science in Sports and Exercise·Zhen WangJunping Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.