Autophagy and mitophagy in hepatocarcinogenesis

Molecular & Cellular Oncology
Kai LiuJing-Hsiung James Ou

Abstract

Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the transcription factor NANOG to maintain hepatic cancer stem cells and promote hepatocarcinogenesis.

References

Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Richard J Youle, Derek P Narendra
Apr 19, 2011·Genes & Development·Akito TakamuraNoboru Mizushima
May 21, 2014·The International Journal of Biochemistry & Cell Biology·Matthew RedmannJianhua Zhang

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Citations

Jun 19, 2019·Molecular & Cellular Oncology·Juliette Paillet, Guido Kroemer
Nov 13, 2018·World Journal of Gastroenterology : WJG·Fang HuangYi-Gang Wang

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