Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy

International Journal of Nephrology
Suzan A KhodirOmnia Ameen

Abstract

Not only is diabetic nephropathy (DN) the most common cause of end-stage renal disease worldwide, but it also increases the risk of mortality up to fourteen times compared to normoalbuminuric diabetic patients. The aim of the current study was the evaluation of the renoprotective effects of vitamin D in DN and the possible interplay between autophagy and mTOR pathways. Fifty male Wistar albino rats were divided (10/group) into control, DN group, insulin-treated DN group, vitamin D-treated DN group, and combined insulin and vitamin D-treated DN group. Assessments of systolic blood pressure, albuminuria, creatinine clearance, serum glucose, insulin, urea, creatinine, inflammatory cytokines, oxidative stress markers, and rat kidney gene expression of mTOR were performed. Histopathological and immunohistochemical assessments of autophagy marker LC3 in rat kidneys were also performed. DN was associated with significant increases in SBP, urinary albumin, serum glucose, urea, creatinine, inflammatory cytokines, MDA, and mTOR gene expression (P < 0.05). However, there was significant decrease in creatinine clearance, serum insulin, GSH, and H score value of LC3 when compared with control group (P < 0.05). The combination of insulin and...Continue Reading

References

Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Oct 23, 2001·Contributions to Nephrology·K Shikata, H Makino
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yeşim UnlüçerçiGülay Seferoğlu
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Daisuke KoyaMasakazu Haneda
Jun 19, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nurija BilalovicEmina E Torlakovic
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Núria LloberasJosep M Grinyó
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Juan F Navarro-González, Carmen Mora-Fernández
May 5, 2010·Nature Reviews. Nephrology·Piero RuggenentiGiuseppe Remuzzi
Jul 16, 2010·Cardiovascular Therapeutics·Andreas Eisenreich, Ursula Rauch
Jan 26, 2011·Annual Review of Pathology·Yashpal S KanwarSheldon Chen
May 12, 2011·Cell Cycle·Thomas S Lisse, Martin Hewison
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Dec 24, 2011·Journal of the American Society of Nephrology : JASN·Davide P CinàSusan E Quaggin
Nov 29, 2012·BMC Nephrology·María Jesús IzquierdoPedro Abaigar
Aug 27, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Diego C MusialNeide H Jurkiewicz
Apr 30, 2014·Hormones : International Journal of Endocrinology and Metabolism·Chittari Venkata Harinarayan
Jul 16, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Stephen M HewittEduardo Rosa-Molinar
Feb 27, 2015·Diabetology & Metabolic Syndrome·Luciana Sayuri SanadaValéria Paula Sassoli Fazan
Apr 24, 2015·International Urology and Nephrology·Yan Peng, Liu-Juan Li
Oct 23, 2015·Mediators of Inflammation·Gina MandaMihail Eugen Hinescu
Dec 23, 2015·Journal of Endocrinological Investigation·X DengM Shen
Apr 3, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A CerielloS Genovese
Jul 20, 2016·Molecular Medicine Reports·Yubin WangZhengyu Zhou
Aug 11, 2016·Metabolism: Clinical and Experimental·Wei XinQiang Wan
Dec 16, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M P KotlarczykS L Greenspan
Dec 23, 2016·Kidney International·Jeremy S LeventhalMichael J Ross
Feb 6, 2019·Frontiers in Physiology·Yuxue ZhaoWei Jing Liu

Related Concepts

3,4-Methylenedioxyamphetamine
Albumins
Albuminuria
Antioxidants
Autophagy
Biological Markers
Creatinine
Diabetic Nephropathy
Down-Regulation
Gene Expression

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms