Autophagy and Obesity-Related Lung Disease

American Journal of Respiratory Cell and Molecular Biology
Maria A PabonAugustine Mk Choi

Abstract

Obesity-related disease is a significant source of premature death and economic burden globally. It is also a common comorbidity in patients suffering from lung disease, affecting both severity and treatment success. However, this complex association between obesity and the lung is poorly understood. Autophagy is a self-recycling homeostatic process that has been linked to beneficial or deleterious effects, depending on the specific lung disease. Obesity affects autophagy in a tissue-specific manner, activating autophagy in adipocytes and impairing autophagy in hepatocytes, immune cells, and pancreatic β-cells, among others. Obesity is also characterized by chronic low-grade inflammation that can be modulated by the pro- and antiinflammatory effects of the autophagic machinery. Scant evidence exists regarding the impact of autophagy in obesity-related lung diseases, but there are communal pathways that could be related to disease pathogenesis. Important signaling molecules in obesity, including IL-17, leptin, adiponectin, NLRP3 inflammasome, and TLR-4, have been implicated in the pathogenesis of lung disease. These mediators are known to be modulated by autophagy activity. In this perspective, we highlight the recent advances i...Continue Reading

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Citations

Jun 15, 2017·BioMedicine·Jai-Sing YangFuu-Jen Tsai
Sep 29, 2020·Frontiers in Physiology·Héctor A Cruz-ÁvilaEnrique Hernández-Lemus
Jun 5, 2019·The Journal of Clinical Investigation·David Warburton, Saverio Bellusci
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Nov 2, 2021·Chemical & Pharmaceutical Bulletin·Mayuko AkiuTsuyoshi Nakamura

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