Autophagy and pancreas disease

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Maria I Vaccaro

Abstract

Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which has been known for its role in protecting cells against stresses such as starvation and in eliminating defective subcellular structures. It is essentially a form of self-cannibalism - hence the name that means 'self-eating' - in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin et al. in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.

References

Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·H HelinM Helin
Sep 21, 2000·The Journal of Clinical Investigation·W HalangkJ Deussing
Mar 22, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·María I VaccaroM Cristina Cerquetti
Nov 6, 2004·Science·Takahiro Shintani, Daniel J Klionsky
Nov 9, 2004·Current Opinion in Cell Biology·Aimee L Edinger, Craig B Thompson
Nov 20, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Anna S Gukovskaya, Stephen J Pandol
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Oct 4, 2005·The Journal of Clinical Investigation·Beth Levine, Junying Yuan
Oct 18, 2007·The Journal of Biological Chemistry·Alejandro RopoloMaria I Vaccaro

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Citations

Dec 22, 2010·The Journal of Biological Chemistry·Daniel GrassoMaría I Vaccaro
May 3, 2012·International Journal of Cell Biology·Maria I Vaccaro
Feb 1, 2012·International Journal of Cell Biology·Daniel GrassoJuan L Iovanna
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alejandro RopoloMaria I Vaccaro
Dec 17, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Daniel GrassoMaria I Vaccaro
Feb 12, 2017·Clinical Science·Bárbara MaizteguiJuan J Gagliardino

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