Autophagy and Parkinson's Disease

Advances in Experimental Medicine and Biology
Jiahong LuZhenyu Yue

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by motor system dysfunction. The etiology of PD has been linked with aging, environmental toxins and genetic mutation, while molecular pathogenesis of PD includes various factors, such as impaired protein homeostasis, oxidative stress, mitochondria dysfunction, synaptic transmission impairment, calcium homeostasis imbalance, prion-like α-synuclein transmission and neuron inflammation. Autophagy is a conserved bulk degradation process to maintain cellular homeostasis. Impairment of autophagy has been reported to be involved in the pathogenesis of PD. Coding proteins of several PD-related genes, such as SNCA, LRRK2, GBA, ATP13A2, VPS35 and FBXO7, are implicated in or affected by autophagy process. Furthermore, various pathogenic events during PD directly or indirectly interfere with the autophagy pathway, and dysregulation of autophagy has been observed in different neurotoxic PD models. Autophagy has been regarded as a potential therapeutic target for PD treatment. Indeed, modulations of autophagy-regulated genes (BECN1 and TFEB) expression exerted neuroprotection against PD models, and various autophagy regulators, such as rapamycin, treh...Continue Reading

Citations

Jan 5, 2021·Frontiers in Neuroscience·Xiangpeng Ren, Jiang-Fan Chen
Apr 29, 2021·Neural Regeneration Research·Xue ZhangAn-Mu Xie
May 26, 2021·Molecular Neurodegeneration·Souvarish SarkarMel B Feany
Jun 30, 2021·Experimental Neurology·Subramaniam JayanthiJean Lud Cadet

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