Abstract
The intestinal epithelium (IE) forms an indispensible barrier and interface between the intestinal interstitium and the luminal environment. The IE regulates water, ion and nutrient transport while providing a barrier against toxins, pathogens (bacteria, fungi and virus) and antigens. The apical intercellular tight junctions (TJ) are responsible for the paracellular barrier function and regulate trans-epithelial flux of ions and solutes between adjacent cells. Increased intestinal permeability caused by defects in the IE TJ barrier is considered an important pathogenic factor for the development of intestinal inflammation, diarrhea and malnutrition in humans and animals. In fact, defects in the IE TJ barrier allow increased antigenic penetration, resulting in an amplified inflammatory response in inflammatory bowel disease (IBD), necrotizing enterocolitis and ischemia-reperfusion injury. Conversely, the beneficial enhancement of the intestinal TJ barrier has been shown to resolve intestinal inflammation and apoptosis in both animal models of IBD and human IBD. Autophagy (self-eating mechanism) is an intracellular lysosome-dependent degradation and recycling pathway essential for cell survival and homeostasis. Dysregulated autop...Continue Reading
Citations
Dec 19, 2018·International Journal of Radiation Biology·Laura E EwingIgor Koturbash
Mar 16, 2019·Cell Death & Disease·Zhongnan ZhengWei Wu
Jan 4, 2019·Clinical Science·Tzu-Hao LiHan-Chieh Lin
Sep 12, 2019·Acta Pharmacologica Sinica·Xiao-Xia YanLi-Kun Gong
Feb 9, 2020·Microorganisms·Yehao LiuYanli Ji
Feb 8, 2019·Critical Reviews in Food Science and Nutrition·Imam HossenXiao Junsong
Jan 14, 2017·Oncotarget·Guojun WuXingsong Tian
Jun 8, 2017·Frontiers in Pharmacology·Yongjian XiongHuishu Guo
Aug 8, 2018·Nutrients·Leila Abdelhamid, Xin M Luo
Nov 28, 2019·Cell Death & Disease·Lauren G JonesCarrie A Duckworth
Dec 8, 2020·Cutaneous and Ocular Toxicology·Dong Li LiYuan-Yuan Gong
Mar 16, 2021·Frontiers in Oncology·Maria Paz Hernández-CáceresCristina Bertocchi
Apr 8, 2021·PloS One·Rana Al-SadiThomas Y Ma
Apr 29, 2021·Autophagy·Elisabeth G FoersterDana J Philpott
May 22, 2021·Food & Function·Zhen ShiGuo-Wen Liu
Aug 1, 2021·Planta medica·Urszula LatekMarta Mendel
Jul 24, 2021·Molecular Medicine Reports·Huan DuXiaobo Du
Jul 10, 2019·Food Research International·Luana Haselein MaurerTatiana Emanuelli
Oct 29, 2021·Bioengineered·Mingli WangHong Zhang
Oct 30, 2021·Critical Reviews in Food Science and Nutrition·Bing ZhengQiang Yu
Nov 12, 2021·Animal Biotechnology·Guangmang LiuJing Wang
Dec 7, 2021·Frontiers in Microbiology·Fan WanHongfu Zhang