Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor.

Database : the Journal of Biological Databases and Curation
Kelie ChenYihua Wu

Abstract

Autophagy is an essential cellular process that is closely implicated in diverse pathophysiological processes and a variety of human diseases, especially tumors. Autophagy is regarded as not only an anti-cancer process in tumorigenesis but also a pro-tumor process in progression and metastasis according to current research. It means the role of autophagy in tumor is considered to be complex, controversial and context dependent. Hence, a comprehensive database is of great significance to obtain an in-depth understanding of such complex correlations between autophagy and tumor. To achieve this objective, here we developed the Autophagy and Tumor Database (named as ATdb, http://www.bigzju.com/ATdb/#/) to compile the published information concerning autophagy and tumor research. ATdb connected 25 types of tumors with 137 genes required for autophagy-related pathways, containing 219 population filters, 2650 hazard ratio trend plots, 658 interacting microRNAs, 266 interacting long non-coding RNAs, 155 post-translational modifications, 298 DNA methylation records, 331 animal models and 70 clinical trials. ATdb could enable users to search, browse, download and carry out efficient online analysis. For instance, users can make predictio...Continue Reading

References

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Citations

Nov 18, 2020·Briefings in Bioinformatics·Dipanka Tanu SarmahSamrat Chatterjee

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Methods Mentioned

BETA
RNAseq

Software Mentioned

MySQL
ARN
survminer
Firefox
Human Protein Atlas
R package factoextra
ENSEMBL
Linnorm
JAVA
mysqlimport

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