Autophagy as a promoter of longevity: insights from model organisms.

Nature Reviews. Molecular Cell Biology
Malene HansenDavid W Walker

Abstract

Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade indicates that autophagy also has a direct role in modulating ageing. In particular, elegant studies using yeasts, worms, flies and mice have demonstrated a broad requirement for autophagy-related genes in the lifespan extension observed in a number of conserved longevity paradigms. Moreover, several new and interesting concepts relevant to autophagy and its role in modulating longevity have emerged. First, select tissues may require or benefit from autophagy activation in longevity paradigms, as tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan. Second, selective types of autophagy may be crucial for longevity by specifically targeting dysfunctional cellular components and preventing their accumulation. And third, autophagy can influence organismal health and ageing even non-cell autonomously, and thus, autophagy stimulation in select tissues can have beneficial, systemic effects on lifespan. Understanding these mechanisms will be important fo...Continue Reading

References

Nov 30, 1988·Mechanisms of Ageing and Development·G J SarkisL A Jacobson
May 12, 2000·The Journal of Biological Chemistry·A M Cuervo, J F Dice
Jul 11, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A DonatiE Bergamini
Aug 29, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A DonatiE Bergamini
Apr 30, 2002·Human Molecular Genetics·Brinda RavikumarDavid C Rubinsztein
May 7, 2002·American Journal of Human Genetics·Nancy LaurinVincent Raymond
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jessica C GreeneLeo J Pallanck
Apr 30, 2003·The Journal of Biological Chemistry·Julie L WebbDavid C Rubinsztein
May 14, 2003·Experimental Gerontology·Alessandra Del RosoEttore Bergamini
Mar 25, 2004·Aging Cell·Richard A Miller
Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susan J BroughtonLinda Partridge
May 11, 2005·The American Journal of Clinical Nutrition·K Sreekumaran Nair
Dec 22, 2005·Human Molecular Genetics·Zdenek BergerDavid C Rubinsztein
Jan 6, 2007·Autophagy·Eszter S HarsLeroy F Liu
Aug 3, 2007·Cell Cycle·Ju Huang, Daniel J Klionsky
Sep 29, 2007·Current Biology : CB·Wendy M ShawColeen T Murphy
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Mar 5, 2008·Cell Metabolism·David Gems, Linda Partridge
Jun 19, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alessio DonatiEttore Bergamini
Jan 23, 2009·The Biochemical Journal·Susan Broughton, Linda Partridge
Apr 3, 2009·Nature·Rajat SinghMark J Czaja
Oct 6, 2009·Nature Cell Biology·Tobias EisenbergFrank Madeo
Nov 12, 2009·Experimental Gerontology·Stephanie Eva WohlgemuthChristiaan Leeuwenburgh
Mar 26, 2010·Nature·Cynthia J Kenyon
Mar 26, 2010·Nature·Nicholas A BishopBruce A Yankner
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marta M LipinskiJunying Yuan
Sep 22, 2010·The Journal of Cell Biology·Ashley R WinslowDavid C Rubinsztein

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Citations

Jul 31, 2019·The FEBS Journal·Lulu WangBaoming Qin
Jun 22, 2019·Cellular and Molecular Life Sciences : CMLS·Rui LiDing-Sheng Jiang
Nov 7, 2019·Journal of Neurochemistry·Susanna CogoElisa Greggio
Oct 17, 2019·International Journal of Molecular Sciences·Sudip DhakalIan Macreadie
Jan 7, 2020·Experimental Neurobiology·So Yeong CheonJong Eun Lee
Jan 28, 2020·Expert Opinion on Therapeutic Targets·Dorien G De MunckWim Martinet
Feb 6, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bjorn T TamSylvia Santosa
Feb 15, 2020·Alcoholism, Clinical and Experimental Research·Toshimasa TakahashiHerbert Y Gaisano
Sep 8, 2019·Experimental & Molecular Medicine·In Hye Lee
Mar 12, 2020·International Journal of Molecular Sciences·Hiroyuki YamakawaShinsuke Yuasa
Jun 23, 2020·EMBO Reports·Maja C FunkMichael Boutros
Jul 12, 2019·Scientific Reports·Matthew C TillmanEric A Ortlund
Sep 21, 2020·Aging Cell·Yixuan FangJianrong Wang
Oct 12, 2019·Npj Aging and Mechanisms of Disease·Tugsan TezilEric Verdin
Mar 16, 2019·International Journal of Molecular Sciences·Anna Bielak-ZmijewskaEwa Sikora
May 28, 2019·Scientific Reports·Joseph M SchinamanDavid W Walker
Jul 10, 2019·Annual Review of Cell and Developmental Biology·Hideaki Morishita, Noboru Mizushima
Nov 15, 2019·The Journal of Cell Biology·Caroline Kumsta, Malene Hansen
Jan 16, 2020·Nature Reviews. Molecular Cell Biology·Grace Y Liu, David M Sabatini
Aug 25, 2020·Science Advances·Melissa G MetcalfAndrew Dillin
Feb 21, 2019·Nature Communications·Shuhei NakamuraTamotsu Yoshimori
May 31, 2019·Human Genetics·Shi Q WongLouis R Lapierre
Feb 8, 2019·Cell Death and Differentiation·Maria Chiara Maiuri, Guido Kroemer
Mar 28, 2019·Frontiers in Aging Neuroscience·David A Loeffler

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Methods Mentioned

BETA
electron microscopy
gene knockout
nuclear translocation

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