Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

Cells
David E LeeJames P White

Abstract

Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function.

References

Nov 10, 1977·Nature·G E Mortimore, C M Schworer
Apr 1, 1991·Journal of Applied Physiology·J O Holloszy, K B Schechtman
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·H G FehrH Michna
Aug 1, 1971·The Anatomical Record·F P Moss, C P Leblond
Dec 1, 1982·Mechanisms of Ageing and Development·E Schultz, B H Lipton
Feb 1, 1997·Journal of Applied Physiology·J O Holloszy
Jan 6, 2000·Experimental Gerontology·E KoikeM Murakami
Jan 19, 2000·Neurobiology of Aging·J R Vanfleteren, B P Braeckman
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Feb 22, 2001·The Journal of Clinical Investigation·C HerreroA Celada
Mar 8, 2002·Clinical and Experimental Immunology·M SandmandB K Pedersen
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary RenshawSuryaprakash Sambhara
Aug 16, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher R RathboneR B Armstrong
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
May 1, 1963·Scientific American·C DE DUVE
Nov 30, 1964·Annals of the New York Academy of Sciences·A N STUDITSKY
Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Feb 8, 2006·Experimental and Molecular Pathology·Massimo De MartinisLia Ginaldi
Sep 1, 2006·Experimental Gerontology·Sameer S JejurikarWilliam M Kuzon
Oct 6, 2006·Molecular Biology of the Cell·Zhifen YangDaniel J Klionsky
Jan 16, 2007·Stem Cells·Charlotte A CollinsTerence A Partridge
Jan 17, 2007·Autophagy·Jolene BohenskyVickram Srinivas
Feb 27, 2007·The American Journal of Pathology·Machteld J van AmerongenMarja J A van Luyn
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Jun 14, 2008·Cell Death and Differentiation·I PapandreouN C Denko
Jun 24, 2008·Molecular Cell·Yongjie WeiBeth Levine
Mar 5, 2009·The Journal of Biological Chemistry·Ian G GanleyXuejun Jiang
Mar 18, 2009·Molecular and Cellular Biology·Tamara CopettiClaudio Schneider
Apr 3, 2009·Nature·Rajat SinghMark J Czaja
Jun 23, 2009·Nature·Koichi ArakiRafi Ahmed
Aug 25, 2009·The Journal of Physiological Sciences : JPS·Naomi E BrooksRobert S Hikida
Oct 6, 2009·Nature Cell Biology·Tobias EisenbergFrank Madeo
Nov 10, 2009·Journal of Comparative Pathology·G PawelecE Derhovanessian
Dec 1, 2009·Cell Metabolism·Eva MasieroMarco Sandri
Apr 9, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiroshi KogaAna Maria Cuervo
Apr 28, 2010·PLoS Genetics·Mirela MatecicJeffrey S Smith
Jun 16, 2010·Cell Research·Maryam MehrpourPatrice Codogno
Jun 19, 2010·Biogerontology·T FulopG Pawelec

❮ Previous
Next ❯

Citations

Apr 23, 2020·Antioxidants·Francesca PacificiDavide Lauro
Apr 8, 2020·Journal of Neuroinflammation·Mei-Ling XiaGang Hu
Dec 8, 2019·Nutrients·Ki Wung Chung, Hae Young Chung
Jun 6, 2020·International Journal of Molecular Sciences·Alessandra BolottaCinzia Zucchini
Sep 29, 2020·Frontiers in Physiology·Brandon N VanderVeenJames A Carson
Oct 18, 2020·International Journal of Molecular Sciences·Mirko PesceAntonia Patruno
Jan 27, 2021·Journal of Physiology and Biochemistry·Iwan SetiawanHanna Goenawan
Nov 26, 2019·Experimental Gerontology·Jiling LiangNing Chen
Jan 10, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Cinzia BragatoMarina Mora
Feb 11, 2020·Chemical Science·Xiujuan ShiBen Zhong Tang
Aug 28, 2021·International Journal of Molecular Sciences·Rosa MancinelliGiorgio Fanò-Illic
Dec 14, 2021·Frontiers in Physiology·Hui-Ying LukJakob L Vingren

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Molecular Aspects of Medicine
Pedro Sousa-Victor, Pura Muñoz-Cánoves
Current Topics in Developmental Biology
Yunjoon Jung, Andrew S Brack
Molecular and Cellular Endocrinology
Laura García-Prat, Pura Muñoz-Cánoves
© 2022 Meta ULC. All rights reserved