Autophagy, autoimmunity and autoimmune diseases

Médecine sciences : M/S
Sylviane Muller


Autoimmune diseases such as systemic lupus, are the consequence of immunity directed against the organism itself. The immune system abnormally recognizes self-components as foreign and produces antibodies targeting normal cells and tissues. We and others have discovered a number of failures affecting autophagy pathways in the lymphocytes of model mice and patients with lupus. While the current treatments are mainly based on immunosuppressive drugs that can lead to important side effects, the synthetic phosphopeptide P140/Lupuzor, which targets chaperone-mediated autophagy and displays no side effects, holds a lot of promise as a drug candidate. P140, which is currently evaluated in a phase III clinical trial, targets chaperone-mediated autophagy that is hyperactivated in lupus mice, and reduces antigenic peptides presentation to autoreactive helper T cells. Remarkably, we showed in lupus mice that upon treatment with P140, a number of immunological abnormalities affecting the pool of T and B cells as well as many biological and clinical features no longer occur.


Mar 26, 2002·Nature Reviews. Immunology·Carol L Vanderlugt, Stephen D Miller
Jul 13, 2002·Arthritis and Rheumatism·F Monneaux, Sylviane Muller
May 15, 2004·Science·J Magarian Blander, Ruslan Medzhitov
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jörn DengjelStefan Stevanovic
Aug 16, 2006·The Journal of Experimental Medicine·Lélia DelamarreE Sergio Trombetta
Dec 22, 2006·The Journal of Biological Chemistry·Sovan SarkarDavid C Rubinsztein
Dec 28, 2006·The Journal of Experimental Medicine·Heather H PuaYou-Wen He
Jan 22, 2008·Nature Genetics·International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)Jennifer A Kelly
Feb 11, 2010·Cell·Noboru MizushimaBeth Levine
Feb 12, 2010·The Journal of Biological Chemistry·Maurizio RennaDavid C Rubinsztein
Aug 12, 2010·Annals of the Rheumatic Diseases·Casandra C van BavelJohan van der Vlag
Dec 18, 2010·Nature Chemical Biology·Angeleen FlemingDavid C Rubinsztein
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jennifer MartinezDouglas R Green
Apr 24, 2012·Autophagy·Frédéric GrosSylviane Muller
Jul 28, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristiano AlessandriMarina Pierdominici
Nov 28, 2012·Current Opinion in Immunology·Jessica M MoffatJose A Villadangos
Jan 23, 2013·EMBO Reports·Suresh Subramani, Vivek Malhotra
Aug 27, 2013·Immunity·Yuting MaGuido Kroemer
Sep 26, 2013·Nature Reviews. Immunology·Vojo DereticShizuo Akira
Nov 28, 2013·Cell Research·Ana Maria Cuervo, Esther Wong
Dec 7, 2013·Frontiers in Immunology·Kyung-Jin Cho, Paul A Roche
Dec 11, 2013·The Journal of Cell Biology·Susana RomaoChristian Münz
Dec 25, 2013·Cell Research·Yuchen FengDaniel J Klionsky
Jan 15, 2014·Annals of the Rheumatic Diseases·Alexander J ClarkeTimothy J Vyse
Jun 7, 2014·British Journal of Pharmacology·Frédéric Gros, Sylviane Muller
Feb 6, 2015·The Journal of Clinical Investigation·Beth LevinePatrice Codogno
Feb 27, 2015·Autophagy·Christophe MacriSylviane Muller
Feb 28, 2015·Nature Reviews. Immunology·Paul A Roche, Kazuyuki Furuta
May 9, 2015·Molecular Immunology·Sarah N Deffit, Janice S Blum
Jun 24, 2015·The Journal of Experimental Medicine·David C RubinszteinVojo Deretic
Sep 19, 2015·Nature Immunology·Shusaku ShibutaniTamotsu Yoshimori
Nov 21, 2015·Cell Death and Differentiation·J ArnoldFrédéric Gros
Feb 5, 2016·Nature Medicine·Sylviane Muller, Marko Radic
Feb 26, 2016·Science Signaling·Pablo MardonesClaudio Hetz
Mar 25, 2016·Médecine sciences : M/S·Johan ArnoldFrédéric Gros
May 7, 2016·European Journal of Immunology·Yair BotbolFernando Macian
Jun 21, 2016·Immunological Reviews·Christian Münz
Feb 28, 2017·Médecine sciences : M/S·Nadine DraginSonia Berrih-Aknin


Sep 19, 2019·Médecine sciences : M/S·Mathilde GalaisMartine Biard-Piechaczyk

Related Concepts

Autoimmune Diseases
Programmed Cell Death, Type II
Lupus Erythematosus, Systemic
Autoimmune Response
Antigen Processing
Mouse, Swiss
Autoimmune Diseases

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