Autophagy-based survival prognosis in human colorectal carcinoma

Oncotarget
Maopeng YangBin Zhao

Abstract

The role of autophagy in cancers is controversial. Here we aim to determine the prognostic significance of autophagy in colorectal carcinoma patients, thereby allowing more rational development of therapeutic strategies. Through transmission electron microscopy, our data first demonstrated high frequency of defective mitochondria was strongly associated with poor overall survival in colorectal carcinoma. Next immunohistochemical study showed the expressions of Beclin 1, LC3B and Bcl-xL in both the center of tumor and adjacent noncancerous mucosal region were also correlated with overall survivals. We developed an autophagy signature for prognosis based on these three major autophagic proteins, further analysis suggested it was an independent prognostic biomarker and had its value even within single clinical stage. Combined TNM stage and this signature could significantly improve the accuracy of survival prognosis. To validate these immunohistochemical results, an internal testing cohort and an independent population were also included. Our findings suggest that autophagy plays an important role in the clinical cancer progression. Therefore autophagic proteins may be valuable prognostic biomarkers in the therapy of colorectal ca...Continue Reading

References

Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Apr 8, 2004·Developmental Cell·Beth Levine, Daniel J Klionsky
Apr 21, 2007·The EMBO Journal·M Chiara MaiuriGuido Kroemer
May 19, 2007·Genes & Development·Robin MathewEileen White
Jul 4, 2007·Genes & Development·Vassiliki Karantza-WadsworthEileen White
Apr 22, 2008·Methods in Molecular Biology·Isei TanidaEiki Kominami
Sep 23, 2008·Cell Death and Differentiation·M C MaiuriG Kroemer
Oct 8, 2008·The Journal of Cell Biology·Michael DegtyarevKui Lin
Nov 26, 2008·Oncogene·A F Hezel, N Bardeesy
Jan 20, 2009·Cold Spring Harbor Symposia on Quantitative Biology·V KrizhanovskyS W Lowe
Mar 13, 2009·Genes & Development·Andrew R J YoungMasashi Narita
Mar 23, 2010·Lancet·David CunninghamNaureen Starling
Sep 30, 2010·Journal of Clinical Pathology·Alexandra GiatromanolakiEfthimios Sivridis
Dec 4, 2010·Science·Joshua D Rabinowitz, Eileen White
Jan 14, 2011·Cancer Biology & Therapy·Ning Chen, Vassiliki Karantza
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
May 14, 2011·Autophagy·Eeva-Liisa EskelinenPer O Seglen
Nov 1, 2011·Nature Medicine·Kristin M NiemanErnst Lengyel
Dec 8, 2011·World Journal of Gastroenterology : WJG·Gui-Fang GuoLiang-Ping Xia
Mar 20, 2012·Cell·Jodi Nunnari, Anu Suomalainen
Sep 1, 2012·Nature Reviews. Drug Discovery·David C RubinszteinBeth Levine
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun
May 10, 2013·The New England Journal of Medicine·Andrea DoriaLeonardo Punzi
Jan 10, 2014·Nature Reviews. Molecular Cell Biology·Guillermo MariñoGuido Kroemer

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Citations

Jul 12, 2017·International Journal of Molecular Sciences·Svetlana Bortnik, Sharon M Gorski
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·Mija MarinkovićIvana Novak
Nov 16, 2016·Nature Reviews. Clinical Oncology·Lorenzo GalluzziGuido Kroemer
Sep 16, 2020·British Journal of Cancer·Max PiffouxPhilippe A Cassier
Nov 16, 2017·Oncotarget·Bin Zhao, Hong Zhao
Aug 2, 2017·Cancer Biomarkers : Section a of Disease Markers·Lina DengDan Deng
Dec 28, 2019·The Journal of Pathology·Koichiro HarukiShuji Ogino
Feb 8, 2021·Pathology, Research and Practice·Keqian ZhangZhe Wang
Oct 15, 2020·Biomedicines·Rohit GundamarajuSukhwinder Singh Sohal
Jan 10, 2020·Gene·Elmira Roshani-AslYousef Rasmi

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Methods Mentioned

BETA
transmission electron microscopy

Software Mentioned

MedCalc

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