Autophagy chews Fap to promote apoptosis

Nature Cell Biology
Sanket Joshi, Kevin M Ryan

Abstract

Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.

References

May 2, 2003·Molecular and Cellular Biology·Vladimir N IvanovZe'ev Ronai
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li YuMichael Lenardo
Apr 21, 2007·The EMBO Journal·M Chiara MaiuriGuido Kroemer
Oct 31, 2008·Nature Reviews. Molecular Cell Biology·Guido Kroemer, Beth Levine
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
May 30, 2012·Journal of Cell Science·Emma Y Liu, Kevin M Ryan
Oct 18, 2012·Annual Review of Pathology·Lyndsay Murrow, Jayanta Debnath

❮ Previous
Next ❯

Citations

Nov 18, 2014·Marine Drugs·Ammad Ahmad FarooqiHsueh-Wei Chang
Feb 2, 2017·Scientific Reports·Hao-Yuan WangShi-Zhong Zhang
Jun 24, 2017·International Journal of Molecular Sciences·Yu-Tsai LinChih-Yen Chien
Mar 22, 2020·Journal of Biomedical Materials Research. Part a·Guoyan XianPuyi Sheng
Feb 14, 2021·Cells·Sara Marmolejo-Martínez-ArteseroDavid Romeo-Guitart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms