Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment

Cancer Letters
Hao-Zheng YangHan-Bing Zou

Abstract

Currently, chemoresistance is an important cause of treatment failure in colorectal cancer. Cancer stem cells, which are a population of multi-potent cells with the capacity to self-renew and differentiate, have been found to participate in chemoresistance. In the present study, the chemotherapeutic drug oxaliplatin induced autophagy in colorectal cancer cell lines, which in turn protected cancer cells from apoptosis. Further results showed that oxaliplatin-induced autophagy enriched the population of colorectal CSCs and participated in maintaining the stemness of colorectal CSCs, thus making the cells more resistant to chemotherapy. Taken together, the results indicate that autophagy might enhance the chemoresistance of colorectal cancer cells by protecting the stemness and chemoresistance of colorectal CSCs. Our study demonstrates that autophagy plays a pro-survival role in colorectal CSCs subjected to oxaliplatin. Therefore, targeting autophagy may be considered as a potential therapeutic strategy to address chemoresistance in the treatment of colorectal cancer.

References

Mar 27, 2001·The Journal of Cell Biology·N MizushimaT Yoshimori
Mar 21, 2003·The Biochemical Journal·Seyed Ali MousaviRune Kjeken
May 4, 2005·The Journal of Cell Biology·Masaaki KomatsuTomoki Chiba
Jan 20, 2007·The Journal of Clinical Investigation·Ravi K AmaravadiCraig B Thompson
Mar 3, 2007·Leukemia·A ErtmerH M Schätzl
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiangbing ZhouYing Zhang
Nov 2, 2007·Nature Reviews. Cancer·Robin MathewEileen White
Mar 5, 2008·Cancer Research·Anja ApelAndreas Mayer
Jul 30, 2008·Annals of Surgical Oncology·Naotsugu HaraguchiMasaki Mori
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lei DuQuan Chen
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Peter ChuRobert J Peach
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anna DubrovskaVenkateshwar A Reddy
Mar 5, 2009·Journal of Mammary Gland Biology and Neoplasia·Bhuvanesh Dave, Jenny Chang
Jun 16, 2009·Cell·Robin MathewEileen White
Sep 4, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lucia Ricci-VitianiRuggero De Maria
Nov 28, 2009·Nature Reviews. Clinical Oncology·Cornelis J A Punt, Jolien Tol
Feb 11, 2010·Cell·Noboru MizushimaBeth Levine
Jul 5, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hassan ChaachouayH Peter Rodemann
Oct 26, 2011·Current Stem Cell Research & Therapy·Eleazar Lara-Padilla, Julio Roberto Caceres-Cortes
Jan 21, 2012·The Journal of Pathology·Vanessa RauschIngrid Herr
Mar 24, 2012·Cancer Cell·Jeffrey A MageeSean J Morrison
Jun 19, 2012·Cell Stem Cell·Jane E Visvader, Geoffrey J Lindeman
Sep 11, 2012·Autophagy·Chang GongMaryam Mehrpour
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 20, 2013·Autophagy·Hana SchmeisserKathryn C Zoon
Mar 16, 2013·EMBO Molecular Medicine·Huize PanJuan Carlos Izpisua Belmonte
Mar 25, 2014·Journal of Cancer Research and Clinical Oncology·Caroline Palmeira dos SantosClaudia Bincoletto
Apr 1, 2014·Cell Death and Differentiation·S ColakJ P Medema

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Citations

Dec 24, 2015·Oxidative Medicine and Cellular Longevity·Alex Lyakhovich, Matilde E Lleonart
Jul 20, 2016·Cancer Treatment Reviews·A CarneroM E LLeonart
Sep 11, 2016·Biochemical and Biophysical Research Communications·Xiaotong TanShow-Mei Chuang
Dec 28, 2019·BioFactors·Erfan TavanaAmirhossein Sahebkar
Jul 19, 2020·Cells·José Manuel García-Heredia, Amancio Carnero
Sep 12, 2020·Cell Proliferation·Jiali LongWei Zhu
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Nov 20, 2016·Journal of Biomedical Science·Dong ZhangChengwei Liang

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