Autophagy does not lead to the asymmetrical hippocampal injury in chronic stress

Physiology & Behavior
Gonglin HouTi-Fei Yuan

Abstract

Chronic stress results in hippocampal injury, and impairs learning and memory ability of animals. However the cellular mechanisms underlying cell death within hippocampus remain elusive. The present employed the rat model of chronic unpredicted mild stress (CUMS) and examined the cellular mechanism responsible for learning and memory impairments. The results showed that in correlation to the decreased ability in novelty cognition and reverse learning, CUMS led to loss of CA3 neurons in hippocampus, especially in the right hippocampus. Interestingly, autophagy contributed to the cell loss but was asymmetrical on both sides. This suggested that CUMS resulted in asymmetrical hippocampal injuries, which is not fully determined by autophagy.

References

Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Ryan L Wright, Cheryl D Conrad
Nov 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cheryl D Conrad
Dec 19, 2009·Hippocampus·A SamaraG Th Tsangaris
Apr 27, 2011·Frontiers in Neuroinformatics·Lisa J KjonigsenJan G Bjaalie
Jan 31, 2012·Psychiatry Research·Austin A Woolard, Stephan Heckers
Nov 21, 2012·Nature Reviews. Neuroscience·Miguel L ConchaStephen W Wilson
Jan 4, 2013·Neurochemical Research·Gonglin HouTi-Fei Yuan
Dec 18, 2013·CNS Neuroscience & Therapeutics·Gonglin HouTi-Fei Yuan
Jan 1, 2014·The Journal of Sexual Medicine·Gonglin HouTi-Fei Yuan
Jun 1, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ti-Fei Yuan, Burton M Slotnick
Jan 24, 2015·CNS & Neurological Disorders Drug Targets·Ti-Fei YuanOscar Arias-Carrión

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Citations

Dec 5, 2015·Frontiers in Behavioral Neuroscience·Ti-Fei Yuan, Gonglin Hou
Aug 28, 2021·Frontiers in Molecular Neuroscience·Jorge A Sierra-FonsecaKristin L Gosselink

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