Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Neuropsychiatric Disease and Treatment
Zhiyou CaiBin Zhao

Abstract

Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer's disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer's disease, the present study was implemented to investigate the effects of autophagy on α-secretase, β-secretase, or γ-secretase, and observe the effects of autophagy on autophagic clearance markers. These results showed that both autophagy inhibitor and inducer enhanced the activity of α-, β-, and γ-secretases, and Aβ production. Autophagy inhibitor may more activate γ-secretase and promote Aβ production and accumulation than its inducer. Both autophagy inhibitor and inducer had no influence on Aβ clearance. Hence, autophagy inhibitor may activate γ-secretase and promote Aβ production and accumulation, but has no influence on Aβ clearance.

Citations

Jul 19, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pei-Pei Guan, Pu Wang
Jun 27, 2018·Chinese Medical Journal·Yi-Gang Chen
Sep 11, 2019·CNS Neuroscience & Therapeutics·Huang KuangShu-Long Yang
Mar 13, 2020·Neurochemical Research·Yan YanHaibing Yu
May 28, 2019·The International Journal of Neuropsychopharmacology·Hye Jeong LeeHyeon Soo Kim
Feb 15, 2018·Frontiers in Aging Neuroscience·Md Sahab UddinAdrian M Stankiewicz
Jun 24, 2018·International Journal of Molecular Sciences·Sindhu RameshMuralikrishnan Dhanasekaran
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Dec 29, 2020·Journal of Alzheimer's Disease : JAD·Yang-Yang WangZhi-You Cai
Mar 7, 2021·Biomedicines·Nuno Santos Leal, Luís Miguel Martins

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Methods Mentioned

BETA
PCR
electrophoresis
ELISA

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