Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Cellular and Molecular Life Sciences : CMLS
Danyi YangZheng Dong

Abstract

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.

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Methods Mentioned

BETA
biopsy
transmission electron microscopy
protein folding
fluorescence microscopy
biopsies

Related Concepts

Metazoa
Programmed Cell Death, Type II
Nodular Glomerulosclerosis
Kidney
Signal Transduction
Innovative Therapies
Podocytes
Autophagy
Diabetes
Glycosuria, Renal

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