Autophagy in diabetic nephropathy

The Journal of Endocrinology
Yan Ding, Mary E Choi


Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide, and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Increasing prevalence of diabetes has made the need for effective treatment of DN critical and thereby identifying new therapeutic targets to improve clinical management. Autophagy is a highly conserved 'self-eating' pathway by which cells degrade and recycle macromolecules and organelles. Autophagy serves as an essential mechanism to maintain homeostasis of glomeruli and tubules, and plays important roles in human health and diseases. Impairment of autophagy is implicated in the pathogenesis of DN. Emerging body of evidence suggests that targeting the autophagic pathway to activate and restore autophagy activity may be renoprotective. In this review, we examine current advances in our understanding of the roles of autophagy in diabetic kidney injury, focusing on studies in renal cells in culture, human kidney tissues, and experimental animal models of diabetes. We discuss the major nutrient-sensing signal pathways and diabetes-induced altered intracellular metabolism and cellular events, including accumulation of advanced glycation e...Continue Reading


Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A de A Barbosa JúniorU Pfeifer
Jan 1, 1987·Annual Review of Nutrition·G E Mortimore, A R Pösö
Sep 22, 2001·The New England Journal of Medicine·E J LewisCollaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerRENAAL Study Investigators
Dec 12, 2001·Kidney International·J P van KatsA H Danser
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Daisuke KoyaMasakazu Haneda
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Coen D A Stehouwer
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernando C FervenzaMayo Nephrology Collaborative Committee
May 20, 2004·Kidney International·Sira SooparbHarold A Franch
Dec 21, 2005·Biochemical and Biophysical Research Communications·Masayoshi SakaguchiAtsunori Kashiwagi
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Núria LloberasJosep M Grinyó
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Atsuhiro IchiharaTadashi Inagami
Oct 5, 2006·American Journal of Physiology. Renal Physiology·Myung-Ja LeeBalakuntalam S Kasinath
Apr 10, 2007·Seminars in Nephrology·Adeline L Y TanMark E Cooper
Jun 1, 2007·Journal of the American Society of Nephrology : JASN·Hidena TakahashiHiroshi Itoh
Aug 3, 2007·American Journal of Nephrology·Yi YangJianghua Chen
Nov 10, 2007·The American Journal of Pathology·Kavithalakshmi SataranatarajanBalakuntalam S Kasinath
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·In Hye LeeToren Finkel
Sep 9, 2008·Journal of the American Society of Nephrology : JASN·Maja T LindenmeyerDetlef Schlöndorff
May 1, 2009·Nature Reviews. Drug Discovery·Nigel A CalcuttAnn Marie Schmidt
May 9, 2009·Biochemical and Biophysical Research Communications·Hiroyuki MoriAkihiko Yoshimura
Oct 31, 2009·Journal of the American Society of Nephrology : JASN·Wilfred Lieberthal, Jerrold S Levine
Nov 7, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil Nair, John P H Wilding
Nov 18, 2009·Journal of the American Society of Nephrology : JASN·Genevieve Nguyen, Dominik N Muller
Dec 30, 2009·The Journal of Clinical Investigation·Kasper M A RouschopBradly G Wouters
Jan 20, 2010·Current Opinion in Anaesthesiology·Bassam KadryAlex Macario
Jan 26, 2010·Current Opinion in Cell Biology·Congcong He, Beth Levine
Feb 13, 2010·The American Journal of Pathology·Ling LiFangming Lin
Mar 5, 2010·The Journal of Clinical Investigation·Björn HartlebenTobias B Huber
Mar 25, 2010·American Journal of Nephrology·Da-Fa DingYi-Bing Lu
Mar 26, 2010·The Journal of Clinical Investigation·Wenjuan HeChuan-Ming Hao
May 5, 2010·Nature Reviews. Nephrology·Piero RuggenentiGiuseppe Remuzzi
May 21, 2010·American Journal of Physiology. Cell Physiology·Anju YadavPravin C Singhal
Jun 30, 2010·Archives of Physiology and Biochemistry·Jelizaveta SokolovskaNikolajs Sjakste
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Jonas SieberAndreas Werner Jehle
Sep 4, 2010·Circulation Research·Sarah Hummasti, Gökhan S Hotamisligil
Sep 30, 2010·The Journal of Biological Chemistry·Yan DingMary E Choi
Oct 21, 2010·Physiological Reviews·Brinda RavikumarDavid C Rubinsztein
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Nov 4, 2010·Nature Reviews. Nephrology·Takahiko NakagawaQiuhong Li
Nov 13, 2010·PloS One·Jong Woo LeeHong-Gang Wang
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Jan 26, 2011·Annual Review of Pathology·Yashpal S KanwarSheldon Chen
Jan 29, 2011·American Journal of Physiology. Renal Physiology·Franck BelibiCharles L Edelstein
Mar 25, 2011·American Journal of Physiology. Renal Physiology·Michael S ForbesRobert L Chevalier
Apr 16, 2011·Journal of the American Society of Nephrology : JASN·Tomonori KimuraYoshitaka Isaka
May 25, 2011·The Journal of Clinical Investigation·Markus GödelTobias B Huber
May 25, 2011·The Journal of Clinical Investigation·Ken InokiKun-Liang Guan
Jun 8, 2011·Autophagy·Dalibor MijaljicaRodney J Devenish
Oct 26, 2011·Molecular and Cellular Biology·Sebastian AlersBjörn Stork
Oct 29, 2011·Journal of the American Society of Nephrology : JASN·Fabian RiedigerDominik N Muller
Nov 5, 2011·Journal of the American Society of Nephrology : JASN·Yoichi OshimaHiroshi Itoh
Nov 17, 2011·Nephrology·Wan-Young KimYong Kyun Kim
Mar 23, 2012·Journal of Bioenergetics and Biomembranes·Belma TuranGuy Vassort
May 9, 2012·Mechanisms of Ageing and Development·Sifang ZhangXiangmei Chen
Jun 27, 2012·Molecular Biology Reports·Lina WuGuijun Qin
Feb 7, 2013·Experimental Cell Research·Tean MaGuohua Ding
Feb 13, 2013·EMBO Molecular Medicine·Loredana FiorentinoMassimo Federici
Feb 15, 2013·The New England Journal of Medicine·Augustine M K ChoiBeth Levine
Mar 5, 2013·Nature·Maho HamasakiTamotsu Yoshimori
May 7, 2013·Antioxidants & Redox Signaling·Zhibo Wang, Mary E Choi
Aug 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xifeng LuAlexander H Jan Danser
Oct 5, 2013·Journal of the American Society of Nephrology : JASN·Kosuke YamaharaTakashi Uzu
Feb 8, 2014·International Journal of Molecular Medicine·Yanping CaoHuijun Duan
Jun 10, 2014·Lancet·Yuankai Shi, Frank B Hu


Nov 20, 2015·Oxidative Medicine and Cellular Longevity·Yang BaiYang Zheng
Nov 15, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Li XuLining Wang
Feb 11, 2015·DNA and Cell Biology·Adam D Barlow, David C Thomas
Nov 10, 2015·Osteoarthritis and Cartilage·M RibeiroB Caramés
Feb 23, 2017·Scientific Reports·Xu-Shun JiangXiao-Gang Du
Feb 20, 2018·Nature Reviews. Nephrology·Josephine M Forbes, David R Thorburn
Feb 22, 2018·Antioxidants & Redox Signaling·Stefan W RyterMary E Choi
Sep 29, 2017·Cardiovascular Drugs and Therapy·Corey MageeDerek P Brazil
Feb 10, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Laila Ahmed RashedYasmin El-Esawy
Sep 6, 2017·Cellular and Molecular Life Sciences : CMLS·Danyi YangZheng Dong
Feb 9, 2019·International Urology and Nephrology·Dan DongLi Zhang
Apr 2, 2019·Biological & Pharmaceutical Bulletin·Dawei HeZhengyu Zhou
Apr 17, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jianxia MaYukun Li
Jun 4, 2019·Expert Opinion on Therapeutic Targets·Annabelle M WarrenMark E Cooper
Jun 20, 2019·International Journal of Molecular Sciences·Jong Han LeeHee-Sook Jun
Oct 24, 2019·Annual Review of Physiology·Mary E Choi
Jul 28, 2020·American Journal of Physiology. Renal Physiology·Maurice B FluittCarolyn M Ecelbarger
Sep 15, 2016·Journal of Cellular Physiology·Sreenithya RavindranShankar Munusamy
Aug 8, 2019·American Journal of Physiology. Renal Physiology·Yu Ho LeeSo-Young Lee
Feb 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yimin ShiYimeng Li
Jul 20, 2016·Molecular Medicine Reports·Yubin WangZhengyu Zhou
Jun 9, 2017·Current Diabetes Reports·Munehiro KitadaDaisuke Koya
Feb 2, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wanning WangLu Cai
Aug 14, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Di ZhouFan Yi
Oct 22, 2019·Frontiers in Physiology·Xiangming WangWei Jing Liu
Jul 15, 2020·International Urology and Nephrology·Elias A T KochNakhoul Nakhoul
Feb 7, 2017·Journal of Diabetes Research·Selim FakhruddinKeith E Jackson
May 29, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paola PontrelliLoreto Gesualdo
Nov 7, 2019·Indian Journal of Clinical Biochemistry : IJCB·Magdy M MohamedMarwa G A Hegazy
Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Yang ChenYanrong Lu
Jul 25, 2020·Nature Reviews. Nephrology·Chengyuan TangZheng Dong
Jul 5, 2017·Experimental and Therapeutic Medicine·Chun-Shan HanHai-Cheng Gao
Jun 25, 2020·Advances in Nutrition·Vemana GowdKa-Wing Cheng
Mar 19, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Pingping ZhangDongmei Gan
Aug 10, 2017·Journal of Diabetes Research·Haoran DaiBaoli Liu
Aug 18, 2020·The Journal of Clinical Investigation·Zhengwei MaZheng Dong
Oct 25, 2020·BMC Complementary Medicine and Therapies·Yusong NieMiao Yan
Jan 16, 2021·Current Diabetes Reports·Robert C Stanton
Nov 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei-Jun HuangJin-Xi Zhao
Feb 10, 2021·International Journal of Molecular Sciences·Christian Sávio-SilvaÉrika Bevilaqua Rangel
Jan 12, 2021·Frontiers in Medicine·Adamasco CupistiGiorgina B Piccoli
Feb 11, 2021·International Journal of Molecular Sciences·Theodomir DusabimanaSang Won Park
Feb 7, 2021·Nature Reviews. Nephrology·Ralph A DeFronzoAlaa S Awad
Aug 8, 2020·European Journal of Pharmacology·Fengtao LiWenchang Zhao

Related Concepts

Programmed Cell Death, Type II
Diabetes, Autoimmune
Diabetes Mellitus, Non-Insulin-Dependent
Nodular Glomerulosclerosis
Signal Transduction
FKBP12-rapamycin associated protein
Diabetes Mellitus, Non-Insulin-Dependent

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.