Jul 14, 2017

Autophagy in neurodegenerative diseases: pathogenesis and therapy

Brain Pathology
Fang GuoWeidong Le

Abstract

The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy-related pathways as therapeutic targets for the treatment of these diseases.

  • References133
  • Citations9

References

Mentioned in this Paper

Pathogenic Aspects
Biochemical Pathway
Research
Pathogenesis
Huntington's Disease Pathway
Protoplasm
Neurons
Aggregation
Degenerative Diseases, Spinal Cord
Neurodegenerative Disorders Pathway

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