Autophagy in skeletal muscle.

FEBS Letters
Marco Sandri

Abstract

Muscle mass represents 40-50% of the human body and, in mammals, is one of the most important sites for the control of metabolism. Moreover, during catabolic conditions, muscle proteins are mobilized to sustain gluconeogenesis in the liver and to provide alternative energy substrates for organs. However, excessive protein degradation in the skeletal muscle is detrimental for the economy of the body and it can lead to death. The ubiquitin-proteasome and autophagy-lysosome systems are the major proteolytic pathways of the cell and are coordinately activated in atrophying muscles. However, the role and regulation of the autophagic pathway in skeletal muscle is still largely unknown. This review will focus on autophagy and discuss its beneficial or detrimental role for the maintenance of muscle mass.

References

Apr 1, 1972·Journal of Ultrastructure Research·S Schiaffino, V Hanzlíková
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D GomesA L Goldberg
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Giorgia PallafacchinaStefano Schiaffino
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stewart H LeckerAlfred L Goldberg
May 4, 2005·The Journal of Cell Biology·Masaaki KomatsuTomoki Chiba
Jul 19, 2005·Genes & Development·Xiaoxia WangSteven J Burden
Apr 29, 2006·Cell Death and Differentiation·A Hamacher-BradyA B Gustafsson
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Stewart H LeckerWilliam E Mitch
Aug 29, 2006·The American Journal of Pathology·Sachiko HommaShinichi Takayama
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SacheckAlfred L Goldberg
Jun 21, 2007·The Journal of Biological Chemistry·Serhiy PankivTerje Johansen
Sep 6, 2007·Autophagy·Kristin Tracy, Kay F Macleod
Sep 6, 2007·The Journal of Clinical Investigation·Naoki SuzukiShin'ichi Takeda
Oct 16, 2007·Nature Genetics·Julie Pinkston-Gosse, Cynthia Kenyon
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
May 27, 2008·Neuromuscular Disorders : NMD·May Christine MalicdanIchizo Nishino
Jun 6, 2008·The Journal of Biological Chemistry·Yoshinobu IchimuraMasaaki Komatsu
Jun 17, 2008·Physiology·Marco Sandri
Sep 9, 2008·Autophagy·Yoshinobu IchimuraMasaaki Komatsu
Sep 11, 2008·Expert Reviews in Molecular Medicine·Chris D Pacheco, Andrew P Lieberman
Dec 3, 2008·Cell Metabolism·Gabriella DobrowolnyAntonio Musarò
Dec 23, 2008·Autophagy·Michael F N O'Leary, David A Hood
Mar 13, 2009·Genes & Development·Andrew R J YoungMasashi Narita
Apr 10, 2009·American Journal of Physiology. Cell Physiology·Roberta SartoriMarco Sandri
Apr 18, 2009·Biochimica Et Biophysica Acta·Stefania RossiAlessandro Fanzani
May 20, 2009·Molecular Cell·Vladimir KirkinIvan Dikic

❮ Previous
Next ❯

Citations

Jan 15, 2013·Acta Neuropathologica·Nivetha RamachandranBerge A Minassian
Dec 24, 2011·European Journal of Applied Physiology·Cécile JamartMarc Francaux
Dec 30, 2011·Journal of Physiology and Biochemistry·Yong An KimWook Song
Mar 9, 2013·Journal of Physiology and Biochemistry·Yong An KimWook Song
Jul 31, 2013·Trends in Molecular Medicine·Vladimir Ljubicic, Bernard J Jasmin
Nov 5, 2013·Trends in Endocrinology and Metabolism : TEM·Brian A NeelJeffrey E Pessin
Apr 28, 2011·The British Journal of Nutrition·Shaojin ZhangXianghua Yan
Jan 28, 2012·Cell Death and Differentiation·S IovinoF Beguinot
Nov 16, 2012·Cell Death & Disease·C De PalmaE Clementi
Jan 9, 2013·Nature Medicine·Ffolliott Martin Fisher, Eleftheria Maratos-Flier
Feb 22, 2012·Human Molecular Genetics·Natasha C ChangGordon C Shore
Nov 23, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Lars-Eric Thornell
Sep 22, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Chiel de TheijeHarry R Gosker
Mar 1, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Ashok KumarPradyut K Paul
Jul 29, 2010·Current Opinion in Neurology·Conrad C Weihl, Alan Pestronk
Mar 8, 2012·American Journal of Physiology. Endocrinology and Metabolism·Scott K PowersHaydar A Demirel
Mar 17, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ganga GokulakrishnanMarta L Fiorotto
Mar 1, 2012·BMC Developmental Biology·Alexandre Miguel Cavaco RodriguesJuan Carlos Izpisúa Belmonte
Feb 5, 2013·BMC Biology·Bin WeiGuangju Ji
Jul 30, 2011·Skeletal Muscle·Kinga I Gawlik, Madeleine Durbeej
Oct 12, 2012·PloS One·Mahroo MofarrahiSabah N A Hussain
Sep 4, 2013·Journal of Molecular Endocrinology·Keir Menzies, Johan Auwerx
Jan 1, 2011·Polish Journal of Veterinary Sciences·I Otrocka-Domagała
Apr 21, 2012·Advances in Nutrition·John W CarboneStefan M Pasiakos
Nov 5, 2013·Antioxidants & Redox Signaling·Mashrur RahmanSabah N A Hussain
Jan 15, 2014·Journal of Nutritional Science and Vitaminology·Tomonori SatoTakashi Nagasawa
Jan 21, 2014·Journal of Animal Science and Biotechnology·Agus Suryawan, Teresa A Davis
Nov 16, 2013·American Journal of Respiratory and Critical Care Medicine·Yeting GuoSabah N A Hussain
Oct 24, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christopher S FryBlake B Rasmussen
Nov 26, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anna VainshteinPaolo Bonaldo
May 1, 2013·EMBO Molecular Medicine·Ivan NemazanyyGanna Panasyuk
May 21, 2013·Toxicology and Applied Pharmacology·Francesca RovettaMaria Francesca Aleo
Feb 20, 2014·Sports Medicine·Bjorn T Tam, Parco M Siu
Jun 25, 2014·Skeletal Muscle·Vandana A Gupta, Alan H Beggs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms