Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

Stem Cells International
Xihang ChenFeng Lu

Abstract

Autophagy is a highly conserved cellular process that degrades modified, surplus, or harmful cytoplasmic components by sequestering them in autophagosomes which then fuses with the lysosome for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis, as well as for remodeling during normal development. Impairment of this process has been implicated in various diseases, in the pathogenic response to bacterial and viral infections, and in aging. Pluripotent stem cells, with their ability to self-replicate and to give rise to any specialized cell type, are very valuable resources for cell-based medical therapies and open a number of promising avenues for studying human development and disease. It has been suggested that autophagy is vital for the maintenance of cellular homeostasis in stem cells, and subsequently more in-depth knowledge about the regulation of autophagy in stem cell biology has been acquired recently. In this review, we describe the most significant advances in the understanding of autophagy regulation in hematopoietic and mesenchymal stem cells, as well as in induced pluripotent stem cells. In particular, we highlight the roles of various ...Continue Reading

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Citations

Jun 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuehua YangLeisheng Jiang
Sep 17, 2020·Journal of Cellular and Molecular Medicine·Md Abdul Alim Al-Bari
Feb 15, 2019·Frontiers in Microbiology·Shintaro ShimamuraHiroshi Mukae
Aug 8, 2019·International Journal of Molecular Sciences·Larisa RyskalinFrancesco Fornai
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Mehdi NajarHassan Fahmi
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Cristiana PerrottaClara De Palma
Aug 8, 2021·Cells·Giuseppe GarroniMargherita Maioli
Aug 31, 2021·The EMBO Journal·Daniel J KlionskyFederico Pietrocola

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