Autophagy in the Heart

Circulation Journal : Official Journal of the Japanese Circulation Society
Osamu Yamaguchi

Abstract

The autophagic machinery is a well-conserved degradation system in eukaryotes from yeast to mammals. Autophagy has been thought of as a nonselective degradation process in which cytoplasmic proteins and organelles are degraded by fusion with lysosome. Recent studies have revealed selective forms of autophagy, such as mitochondria-specific autophagy, termed "mitophagy". Research over the past decade has revealed that autophagy in cardiomyocytes plays a protective role, not only during hemodynamic stress but in homeostasis during aging. Hemodynamic stress and aging induce mitochondrial damage, leading to increased oxidative stress and decreased ATP production. Damaged mitochondria are generally degraded through mitophagy, which might be the main protective function of autophagy in the heart. Complete digestion of mitochondrial DNA through mitophagy is important to avoid inflammatory responses that can induce heart failure. A polyamine, spermidine, is reported to bring about an extension of lifespan and to protect the heart from age-related cardiac dysfunction, both of which are mediated through induction of autophagy. Therefore, appropriate induction of autophagy could be a novel therapeutic target for cardiovascular diseases, in...Continue Reading

References

Mar 1, 1968·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B BiczowaJ Moore
Dec 1, 1981·Australian and New Zealand Journal of Medicine·B P McGrathC I Johnston
Mar 5, 1999·Science·M W GrayB F Lang
Mar 23, 2001·The Journal of Biological Chemistry·T KataokaJ Tschopp
Jul 11, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A DonatiE Bergamini
Oct 25, 2001·Brain Research. Developmental Brain Research·D P HuynhS M Pulst
Feb 11, 2003·Cell Structure and Function·Noboru MizushimaTamotsu Yoshimori
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Noboru MizushimaYoshinori Ohsumi
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Dec 3, 2003·Trends in Genetics : TIG·Gertraud BurgerB Franz Lang
Jul 13, 2004·The Journal of Biological Chemistry·Ingrid KissováNadine Camougrand
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·E BergaminiZ Gori
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Jul 29, 2006·Autophagy·Ana Maria CuervoAlexei Terman
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Dec 22, 2006·The Journal of Biological Chemistry·Sovan SarkarDavid C Rubinsztein
Jul 4, 2007·The Journal of Clinical Investigation·Hongxin ZhuJoseph A Hill
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rachel L SchweersPaul A Ney
Nov 15, 2008·Cell Death and Differentiation·K NishidaK Otsu
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Dec 9, 2008·Circulation Research·Beverly A Rothermel, Joseph A Hill
Jan 15, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A AvciI Durak
Feb 21, 2009·Cell Death and Differentiation·J Zhang, P A Ney
Jul 22, 2009·Developmental Cell·Tomotake KankiDaniel J Klionsky

❮ Previous
Next ❯

Citations

Nov 25, 2020·Geriatrics & Gerontology International·Takahiro Kamihara, Toyoaki Murohara
Dec 2, 2020·International Journal of Molecular Sciences·Tadashi IchimiyaHiroshi Nakase
Nov 10, 2020·Journal of Cardiovascular Pharmacology·Peng ZhangZhinong Wang
Nov 11, 2020·Experimental Gerontology·Daniel J Moreno Fernández-AyalaGuillermo López-Lluch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Journal of Molecular and Cellular Cardiology
Osamu YamaguchiKinya Otsu
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Sarah E Shires, Åsa B Gustafsson
Autophagy
Ke Wang, Daniel J Klionsky
Seikagaku. The Journal of Japanese Biochemical Society
Yuko HirotaTomotake Kanki
Canadian Journal of Physiology and Pharmacology
Srikanth GivvimaniSuresh C Tyagi
© 2022 Meta ULC. All rights reserved