Autophagy in thyroid cancer: present knowledge and future perspectives

Frontiers in Endocrinology
Romana T Netea-MaierJohannes W A Smit

Abstract

Thyroid cancer is the most common endocrine malignancy. Despite having a good prognosis in the majority of cases, when the tumor is dedifferentiated it does no longer respond to conventional treatment with radioactive iodine, the prognosis worsens significantly. Treatment options for advanced, dedifferentiated disease are limited and do not cure the disease. Autophagy, a process of self-digestion in which damaged molecules or organelles are degraded and recycled, has emerged as an important player in the pathogenesis of different diseases, including cancer. The role of autophagy in thyroid cancer pathogenesis is not yet elucidated. However, the available data indicate that autophagy is involved in several steps of thyroid tumor initiation and progression as well as in therapy resistance and therefore could be exploited for therapeutic applications. The present review summarizes the most recent data on the role of autophagy in the pathogenesis of thyroid cancer and we will provide a perspective on how this process can be targeted for potential therapeutic approaches and could be further explored in the context of multimodality treatment in cancer and personalized medicine.

References

Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M SchlumbergerC Parmentier
Sep 16, 1999·The Journal of Clinical Endocrinology and Metabolism·V LazarM Schlumberger
Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·J I Torréns, H B Burch
Feb 23, 2002·Cell Death and Differentiation·J D BretzJ R Baker
Oct 10, 2002·The Surgical Clinics of North America·Douglas E Wood
Jan 18, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Kip A WestPhillip A Dennis
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Aug 9, 2003·The Journal of Endocrinology·C S MitsiadesN Mitsiades
Oct 11, 2003·Cancer Letters·Laura S WardGustavo H Goldman
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Oct 18, 2005·Current Opinion in Cell Biology·Dos D SarbassovDavid M Sabatini
Nov 17, 2005·Cancer Research·Ginesa García-RostánMassimo Santoro
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
May 27, 2006·European Journal of Endocrinology·Furio PaciniUNKNOWN European Thyroid Cancer Taskforce
Jun 9, 2006·Endocrine Pathology·Svetlana SavinMarija Havelka
Jan 9, 2007·Current Biology : CB·Ryan C ScottThomas P Neufeld
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peng HouMingzhao Xing
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·C DuranteD Russo
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Denise P Carvalho, Andrea C F Ferreira
Dec 21, 2007·Molecular Biology of the Cell·Christopher FungJayanta Debnath
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ezra E W CohenRoger B Cohen
Jun 17, 2008·European Radiology·Thomas J VoglSebastian Lindemayr
Jul 4, 2008·The New England Journal of Medicine·Steven I ShermanUNKNOWN Motesanib Thyroid Cancer Study Group
Jul 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Ana Karina M B SodréRosalinda Y A Camargo
Aug 13, 2008·Toxicology·Wilfried BurschChristopher Gerner
Aug 30, 2008·The Journal of Clinical Investigation·Arkaitz CarracedoPier Paolo Pandolfi
Sep 2, 2008·Cancer Research·Yuhuan LiHong-Ming Hu
Nov 7, 2008·Endocrine-related Cancer·Robert C SmallridgeJohn A Copland
Dec 25, 2008·Neoplasia : an International Journal for Oncology Research·Giuliana CassinelliCinzia Lanzi

❮ Previous
Next ❯

Citations

Sep 22, 2017·Journal of Molecular Endocrinology·Marika H TesselaarTheo S Plantinga
Nov 30, 2019·Current Drug Targets·Liudmila V SpirinaEvgeny A Usynin
Jul 18, 2019·Endocrinology·Tomomi KurashigeYuji Nagayama
Jan 10, 2019·Journal of Asian Natural Products Research·Zhi ChenZi-Ming Feng
Jul 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Wenwen ChaiLiangchun Yang
Jun 2, 2017·Experimental and Therapeutic Medicine·Yifei ZhangXiaojing Song
Nov 2, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yanan ShanZhihua Yin

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
xenograft
biopsies
xenografts

Clinical Trials Mentioned

NCT01141309
NCT01270321
NCT01025453

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Related Papers

Critical Reviews in Oncology/hematology
Huseyin Atakan EkizYusuf Baran
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Christine A Iacobuzio-Donahue
Arquivos brasileiros de endocrinologia e metabologia
Sabrina Mendes CoelhoMário Vaisman
© 2022 Meta ULC. All rights reserved