Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

Neurobiology of Aging
Jae-Kyo JeongSang-Youel Park

Abstract

Sirtuin 1 (Sirt1) is a class III histone deacetylase that mediates the protective effects of neurons in neurodegenerative disorders, including Alzheimer's and prion disease. However, the mechanism directly involved in neuroprotection is still poorly understood. Recent evidence has demonstrated that activating Sirt1 induces autophagy, and that activating autophagy protects neurons against neurodegenerative disorders by regulating mitochondrial homeostasis. Thus, we focused on the mechanism of the Sirt1-mediated neuroprotective effect that was associated with regulating mitochondrial homeostasis via autophagy. Adenoviral-mediated Sirt1 overexpression prevented prion protein (PrP)(106-126)-induced neurotoxicity via autophagy processing. Moreover, Sirt1-induced autophagy protected against the PrP(106-126)-mediated decrease in the mitochondrial membrane potential value. Additionally, Sirt1 overexpression decreased PrP(106-126)-induced Bax translocation to the mitochondria and cytochrome c release into the cytosol. Sirt1 knockdown using small interfering (si) RNAs induced downregulation of Sirt1 protein expression and sensitized neuron cells to PrP(106-126)-induced cell death and mitochondrial dysfunction. Knockdown of autophagy-rela...Continue Reading

References

Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Neena SinghSusamma Verghese
Jan 7, 2006·Nature Medicine·Ingo B Leibiger, Per-Olof Berggren
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver
Jan 12, 2008·Brain : a Journal of Neurology·Tianhong PanJoseph Jankovic
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·In Hye LeeToren Finkel
Jan 27, 2009·Biochimica Et Biophysica Acta·Ning Chen, Vassiliki Karantza-Wadsworth
Mar 3, 2009·Cellular Signalling·Antero Salminen, Kai Kaarniranta
Jun 17, 2009·Cell Host & Microbe·Vojo Deretic, Beth Levine
Mar 13, 2010·The Journal of Pathology·Danielle GlickKay F Macleod
Jul 1, 2010·Expert Review of Neurotherapeutics·Paula I MoreiraGeorge Perry
Jul 24, 2010·The American Journal of Pathology·Zuzana SiskováVictor Hugh Perry
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaday MichánValter D Longo
Oct 27, 2010·Nature Communications·Daniel HerranzManuel Serrano
Nov 16, 2010·Neurobiology of Aging·Jae-Suk SeoSang-Youel Park
Dec 9, 2010·The European Journal of Neuroscience·Mehrdad AlirezaeiJ Lindsay Whitton
Feb 25, 2011·International Journal of Molecular Medicine·Jae-Kyo JeongSang-Youel Park
Apr 5, 2011·International Journal of Alzheimer's Disease·Lucia Pagani, Anne Eckert
Jun 1, 2011·Drug Discovery Today·Ferdinando NicolettiKlaus Bendtzen
Jun 22, 2011·Autophagy·Rui KangDaolin Tang
Jun 28, 2011·International Journal of Molecular Medicine·Jae-Kyo JeongSang-Youel Park
Aug 30, 2011·Biochimica Et Biophysica Acta·Pinar CoskunDouglas C Wallace
Sep 3, 2011·Cell·David C RubinszteinGuido Kroemer
Nov 22, 2011·Cell Cycle·Angelika S Rambold, Jennifer Lippincott-Schwartz

❮ Previous
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Citations

Feb 19, 2013·EMBO Molecular Medicine·Gizem Donmez, Tiago F Outeiro
Apr 30, 2013·Molecular Neurobiology·Xi-Chen ZhuLan Tan
Feb 26, 2013·International Journal of Molecular Sciences·Antero SalminenAnu Kauppinen
Jan 15, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Renzo MancusoXavier Navarro
Dec 11, 2013·Translational Stroke Research·Valérie Petegnief, Anna M Planas
Jan 3, 2016·Prostaglandins & Other Lipid Mediators·Yanlin ZhangYongjun Cao
Aug 27, 2015·Medical Hypotheses·Mark F McCartyJames H O'Keefe
Mar 27, 2015·Journal of Pineal Research·Jae-Kyo Jeong, Sang-Youel Park
Apr 4, 2015·Autophagy·Louis R LapierreMalene Hansen
Mar 31, 2015·Progress in Retinal and Eye Research·Yasunari Munemasa, Yasushi Kitaoka
Feb 24, 2015·Autophagy·Lucia PollettaMarco Tafani
Feb 11, 2014·Neuron·A Zara Herskovits, Leonard Guarente
Mar 8, 2013·Autophagy·Agnes BánrétiYacine Graba
Nov 5, 2014·Acta Neuropathologica·Markus DammeEeva-Liisa Eskelinen
May 27, 2016·Clinical Epigenetics·Vincenzo CarafaLucia Altucci
Dec 5, 2015·Journal of Applied Genetics·Anna Y Tang
Mar 6, 2013·Acta Biochimica Et Biophysica Sinica·Hao YaoLifeng Yang
Oct 25, 2017·Cell and Tissue Research·Marta Cherubini, Richard Wade-Martins
Nov 11, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sang Chul LeeSay-June Kim
Mar 31, 2019·The FEBS Journal·Deepika Puri, Deepa Subramanyam
May 23, 2013·Journal of Cellular Physiology·Fanny Ng, Bor Luen Tang
Oct 22, 2013·International Journal of Molecular Medicine·Myung-Hee MoonSang-Youel Park
Dec 11, 2019·Clinical and Experimental Pharmacology & Physiology·Jiang XuShandong Ye
Sep 8, 2019·Experimental & Molecular Medicine·In Hye Lee
Apr 2, 2020·Expert Opinion on Therapeutic Patents·Nicola MautoneDante Rotili
Aug 9, 2016·Reviews in the Neurosciences·Siew Ying Wong, Bor Luen Tang
Aug 1, 2013·International Journal of Molecular Medicine·Jae-Kyo Jeong, Sang-Youel Park
Sep 19, 2014·International Journal of Molecular Medicine·Yang-Gyu Park, Sang-Youel Park
Dec 13, 2016·Cellular and Molecular Neurobiology·Bor Luen Tang
Feb 15, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lijuan ZhangPeng Fu
May 26, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Teresa Blázquez-SánchezAmélia P Rauter
Sep 30, 2018·Neurochemical Research·Lian LiuZhongyuan Xia
Oct 18, 2019·International Journal of Molecular Sciences·Larisa RyskalinFrancesco Fornai

❮ Previous
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