Autophagy induction in T cell-independent acute hepatitis induced by concanavalin A in SCID/NOD mice

International Journal of Immunopathology and Pharmacology
C-P Chang, H-Y Lei

Abstract

Concanavalin A (Con A) is known to induce acute hepatitis that is mediated by activation of NKT and T-cell and cytokine production in immunocompetent mice. The observation of Con A-induced autophagic cell death of hepatoma cells via a Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 mediated autophagic pathway made us re-evaluate the effect of Con A-induced hepatitis in mice. Con A was administrated intravenously to BABL/c, SCID, or SCID/NOD mice at doses of 20, 30 or 40 mg/kg, respectively, to induce acute hepatitis. The levels of hepatitis and autophagy induction were both analyzed. We found that Con A can induce acute hepatitis in SCID or SCID/NOD mice with kinetics similar to that of BALB/c, but requiring a higher dose of Con A. No lymphocyte infiltrations were found in SCID or SCID/NOD mice, and the cytokine productions were different. An autophagy with microtubule-associated protein light chain 3-II conversion was demonstrated in the liver post-Con A injection in SCID/NOD mice. Due to the mannose/glucose-specific binding on cell membrane, Con A can induce a T-cell-independent acute hepatitis with autophagy in SCID/NOD mice.

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Citations

Aug 23, 2018·International Journal of Molecular Medicine·Dong-Ho BakBeom Joon Kim
Aug 18, 2010·Cancer Metastasis Reviews·Elvira Gonzalez de Mejia, Vermont P Dia
Sep 25, 2014·BioMed Research International·Marouane KheloufiPierre-Emmanuel Rautou
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Sep 3, 2010·Journal of Hepatology·Pierre-Emmanuel RautouRichard Moreau

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