Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells.

Medical Oncology
YaLi RenMing Cheng

Abstract

Autophagy is a survival pathway required for cellular viability during starvation through catabolic self-digestion of damaged proteins and organelles; however, autophagy may result in cell death if it proceeds to completion. Although the exact mechanism of this process is not clear, it seems that proper regulation of autophagy can potentially contribute to the therapeutics of cancers. This study was designed to examine the role of autophagy in the death of human acute promyelocytic leukemia NB4 cells initiated by arsenic trioxide. Furthermore, the effects of autophagy inhibition and augmentation on cell viability were also compared. Our data suggested that both augmentation and suppression of autophagy could enhance the treatment effects while the latter was preferable. This study indicated that autophagy regulation augmented the treatment effects initiated by arsenic trioxide in NB4 cells, and that the selection of regulator should be precisely considered.

References

Jan 25, 2002·Blood·Martin S TallmanJacob M Rowe
Mar 6, 2003·Biochimica Et Biophysica Acta·Eric Ogier-Denis, Patrice Codogno
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Apr 13, 2004·Oncogene·Devrim Gozuacik, Adi Kimchi
Sep 9, 2005·Nature Reviews. Cancer·Yasuko KondoSeiji Kondo
Sep 23, 2006·Cell Death and Differentiation·M J AbedinA Kelekar
Apr 13, 2007·Nature·Beth Levine
Apr 20, 2007·The Journal of Biological Chemistry·Guillermo MariñoCarlos López-Otín
Aug 23, 2007·Nature Reviews. Molecular Cell Biology·Daniel J Klionsky
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·M Chiara MaiuriGuido Kroemer
Nov 30, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David Kessel, Adelaida Segarra Arroyo
Dec 18, 2007·Cell·Andreas Bergmann
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Apr 14, 2009·The Journal of Biological Chemistry·Leonidas C Platanias
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Stephanie L LomonacoChaya Brodie
Mar 4, 2010·Journal of Cellular and Molecular Medicine·L Harhaji-TrajkovicV Trajkovic

❮ Previous
Next ❯

Citations

Dec 2, 2011·PloS One·Fernanda Caroline CarvalhoMaria-Cristina Roque-Barreira
Sep 28, 2015·The International Journal of Biochemistry & Cell Biology·Xin-Yu ZhangYan-Mei Yang
Oct 18, 2014·Annals of Hematology·I Gañán-GómezM C Boyano-Adánez
Feb 17, 2021·Journal of Biochemical and Molecular Toxicology·Zhuo SunYongping Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms