Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation

Cell Host & Microbe
Pauline VerlhacMathias Faure

Abstract

Xenophagy, an essential anti-microbial cell-autonomous mechanism, relies on the ability of the autophagic process to selectively entrap intracellular pathogens within autophagosomes to degrade them in autolysosomes. This selective targeting is carried out by specialized autophagy receptors, such as NDP52, but it is unknown whether the fusion of pathogen-containing autophagosomes with lysosomes is also regulated by pathogen-specific cellular factors. Here, we show that NDP52 also promotes the maturation of autophagosomes via its interaction with LC3A, LC3B, and/or GABARAPL2 through a distinct LC3-interacting region, and with MYOSIN VI. During Salmonella Typhimurium infection, the regulatory function of NDP52 in autophagosome maturation is complementary but independent of its function in pathogen targeting to autophagosomes, which relies on the interaction with LC3C. Thus, complete xenophagy is selectively regulated by a single autophagy receptor, which initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation.

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Citations

Jul 15, 2015·Médecine sciences : M/S·Pauline VerlhacMathias Faure
Jun 25, 2015·Frontiers in Cellular and Infection Microbiology·Shaun SteeleThomas Kawula
May 6, 2016·Cellular and Molecular Life Sciences : CMLS·Amanda S Coutts, Nicholas B La Thangue
Aug 4, 2016·Autophagy·Noelia López-MonteroFrancisco García-Del Portillo
Sep 27, 2016·Trends in Immunology·Christian Münz
May 23, 2017·Viruses·Denitsa S PetkovaMathias Faure
Dec 1, 2017·Viruses·Aurore RozièresMathias Faure
Mar 13, 2018·FEMS Microbiology Reviews·Carolina Agop-NersesianVolker Theo Heussler
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Dec 14, 2017·Essays in Biochemistry·Trond LamarkTerje Johansen
Dec 14, 2017·Essays in Biochemistry·David G McEwan
Nov 15, 2018·Cellular Microbiology·Ching-Yu LinIchiro Nakagawa
Mar 14, 2019·Open Biology·Liliana Echavarria-ConsuegraFulvio Reggiori
Mar 27, 2019·Autophagy·Padhmanand SudhakarIoannis P Nezis
Jun 21, 2019·Journal of Biomedical Science·Mohsen KeshavarzAmir Ghaemi
Jun 10, 2017·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
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