Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity.

Trends in Cancer
E WhiteJessie Yanxiang Guo

Abstract

Autophagy is a catabolic intracellular nutrient-scavenging pathway triggered by nutrient deprivation and stress that captures and degrades intracellular proteins and organelles in lysosomes. The breakdown products are then recycled into metabolic pathways to sustain survival. Organelle turnover by autophagy contributes to quality control and suppresses inflammation. Autophagy is upregulated in many cancers and supports their growth, survival, and malignancy in a tumor cell-autonomous fashion. Host autophagy also promotes tumor growth by maintaining a supply of essential nutrients and suppressing innate and adaptive antitumor immune responses. Autophagy is also upregulated in response to cancer therapy and confers treatment resistance. Thus, autophagy is a cancer vulnerability and its inhibition is under investigation as a novel therapeutic approach.

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Jul 15, 2021·Trends in Molecular Medicine·Noboru MizushimaDavid C Rubinsztein
Jul 28, 2021·Developmental Cell·Laura Poillet-Perez, Eileen White
Aug 8, 2021·International Journal of Molecular Sciences·Angel CayoNelson Brown

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