Autophagy-Related Beclin 1 and Head and Neck Cancers

OncoTargets and Therapy
Yang-Jie HuShui-Hong Zhou

Abstract

Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and increases necrosis and inflammation by impacting apoptotic and autophagic pathways. This paper reviews the relationship between Beclin 1, carcinogenesis and head and neck cancer prognosis.

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Citations

Jun 29, 2021·Journal of Photochemistry and Photobiology. B, Biology·Letícia StefenonMarcelo Sperandio

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Methods Mentioned

BETA
two-hybrid
transfection
biopsies
xenograft

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