Autophagy Snuffs a Macrophage's Inner Fire

Cell Host & Microbe
William Khoury-Hanold, Akiko Iwasaki

Abstract

Autophagy is a well-known cell-intrinsic antiviral defense mechanism. Two new studies published in this issue of Cell Host & Microbe (Lu et al., 2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance.

References

May 1, 2010·Trends in Biochemical Sciences·Robert B Hamanaka, Navdeep S Chandel
May 19, 2010·Cell Host & Microbe·Tamar HermeshCarolina B López
Mar 1, 2012·Science·Ruslan MedzhitovMiguel P Soares

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Citations

Aug 1, 2020·Frontiers in Immunology·Jacob D PainterOmid Akbari

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