Autophagy

Annals of the New York Academy of Sciences
Ameeta Kelekar

Abstract

Autophagy is a major intracellular pathway for the degradation and recycling of long-lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms. Autophagic vacuole formation is also activated as an adaptive response to a variety of extracellular and intracellular stimuli, including nutrient deprivation, hormonal or therapeutic treatment, bacterial infection, aggregated and misfolded proteins and damaged organelles. Mediators of class I and class III PI3 kinase signaling pathways and trimeric G proteins play major roles in regulating autophagosome formation during the stress response. Defective autophagy is the underlying cause of a number of pathological conditions, including vacuolar myopathies, neurodegenerative diseases, liver disease, and some forms of cancer. This chapter provides an overview of the morphology and molecular basis of autophagosome formation and offers a glimpse into the role of autophagy in normal growth and development, while discussing the pathological implications of its deregulation.

References

Oct 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E L PunnonenH Reunanen
Jan 1, 1991·Acta Neuropathologica·K OkamotoM Watanabe
Jun 1, 1990·The Journal of Cell Biology·W A Dunn
Jan 1, 1990·Acta Neuropathologica·Y GotoI Nonaka
Sep 1, 1990·The Journal of Cell Biology·J KopitzP O Seglen
Mar 1, 1988·Annals of Neurology·H KalimoA Salminen
Jan 1, 1966·Annual Review of Physiology·C De Duve, R Wattiaux
Nov 8, 1996·The Journal of Biological Chemistry·E Ogier-DenisP Codogno
Mar 11, 1999·Current Opinion in Genetics & Development·P B DennisG Thomas
Dec 2, 1999·Molecular and Cellular Endocrinology·N S CutlerM E Cardenas
Dec 11, 1999·Current Opinion in Neurology·I Nonaka
Jan 19, 2000·Molecular Biology of the Cell·M HaririI R Nabi
Feb 25, 2000·Photochemistry and Photobiology·D KesselJ J Reiners
Mar 4, 2000·The Biochemical Journal·B Vanhaesebroeck, D R Alessi
Aug 31, 2000·Annual Review of Biochemistry·J Kim, D J Klionsky
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SulzerL Zecca
Nov 23, 2000·European Journal of Cell Biology·H Takano-OhmuroK Morioka
Dec 2, 2000·Science·D J Klionsky, S D Emr
Nov 1, 2001·Annual Review of Cell and Developmental Biology·R KatsoM D Waterfield
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zsolt TallóczyBeth Levine
Feb 22, 2002·Cellular Microbiology·Brian R DornAnn Progulske-Fox
Jan 1, 2003·Current Neurology and Neuroscience Reports·Ichizo Nishino
Feb 11, 2003·Cell Structure and Function·Noboru MizushimaTamotsu Yoshimori
Feb 11, 2003·Cell Structure and Function·Anne PetiotPatrice Codogno
Oct 15, 2003·Neuron·Junying YuanAlexei Degterev
Oct 23, 2003·Human Molecular Genetics·Zheng-Hong QinMarian DiFiglia
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Dec 20, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey H TeckmanDavid Perlmutter
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kenna R MillsJoan S Brugge
Mar 17, 2004·Current Opinion in Pharmacology·Marta M Lipinski, Junying Yuan
Mar 20, 2004·Nature Reviews. Microbiology·Karla KirkegaardWilliam T Jackson
Apr 8, 2004·Developmental Cell·Beth Levine, Daniel J Klionsky
May 8, 2004·Experimental Gerontology·Alexei Terman, Ulf T Brunk
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·E BergaminiZ Gori

❮ Previous
Next ❯

Citations

Sep 28, 2006·Cell and Tissue Research·Athanassios D VelentzasLukas H Margaritis
May 13, 2008·Cancer Metastasis Reviews·Marcel Verheij
Nov 23, 2006·Antioxidants & Redox Signaling·Stefan W RyterAugustine M K Choi
Feb 15, 2011·Carcinogenesis·Cecilia G SanchezRadhika R Pochampally
May 20, 2011·The Journal of Infectious Diseases·Dejiang ZhouStephen A Spector
May 20, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hongyu ZhangLiankun Sun
Apr 18, 2009·Current Opinion in HIV and AIDS·Wendy B Bernstein, Phillip A Dennis
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Brian J Altman, Jeffrey C Rathmell
Dec 27, 2007·Acta Pharmacologica Sinica·Ya-ping YangZheng-hong Qin
Aug 13, 2011·American Journal of Respiratory and Critical Care Medicine·Jeffrey A Haspel, Augustine M K Choi
Feb 18, 2010·Proceedings of the American Thoracic Society·Stefan W RyterAugustine M K Choi
Feb 18, 2010·Proceedings of the American Thoracic Society·Stefan W Ryter, Augustine M K Choi
Mar 19, 2014·International Journal of Cell Biology·Stefan W RyterAugustine M K Choi
Apr 5, 2014·Radiation and Environmental Biophysics·Flávia Maria de Moraes Ramos-PerezSolange Maria de Almeida
Nov 1, 2011·Annual Review of Physiology·Stefan W RyterAugustine M K Choi
Apr 21, 2012·International Journal of Hypertension·Myrna ConstantinStefan W Ryter
Apr 17, 2012·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Meenal Pangare, Ayako Makino
Mar 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ming-Ju HsiehShun-Fa Yang
Sep 20, 2011·Current Opinion in Virology·Brian Yordy, Akiko Iwasaki
Nov 18, 2008·European Journal of Cell Biology·Agnieszka SobolewskaTomasz Motyl
Oct 12, 2013·Redox Report : Communications in Free Radical Research·Lars Folke OlsenBarbara Guerra
Nov 30, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ming-Ju HsiehHui-Ling Chiou
Jul 19, 2013·The Korean Journal of Parasitology·Youn-Jin LeeMyoung-Hee Ahn
Feb 28, 2015·European Journal of Nutrition·Shu-Wen HsuanFen-Pi Chou
Dec 23, 2011·International Journal of Cell Biology·Alexander J S Choi, Stefan W Ryter
Sep 17, 2016·American Journal of Respiratory Cell and Molecular Biology·Sailaja GhantaMark A Perrella
Mar 30, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin D BergerHeinz-Josef Lenz
Apr 11, 2007·Developmental Cell·Zhihua Liu, Michael J Lenardo
Feb 2, 2013·Pulmonary Circulation·Yang Jin, Augustine M K Choi
Sep 22, 2017·International Journal of Molecular Sciences·Hsin-Yuan ChenShih-Min Hsia
Jun 22, 2010·Journal of Cellular Biochemistry·Shelly Adi-HarelRonit Pinkas-Kramarski
Nov 20, 2018·Cell Death & Disease·Ta XiaoHong Yi
Mar 21, 2009·Journal of Cellular and Molecular Medicine·Tri Minh Bui NguyenS Ramakrishnan
Oct 1, 2010·European Journal of Clinical Investigation·Ying-Tse ChangFen-Pi Chou
Dec 25, 2008·Critical Reviews in Clinical Laboratory Sciences·Stefan Holdenrieder, Petra Stieber
Mar 21, 2009·Expert Review of Molecular Diagnostics·Andreas E KremerStefan Holdenrieder
Oct 13, 2009·Expert Review of Gastroenterology & Hepatology·Phillip I BakerLynnette R Ferguson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Antioxidants & Redox Signaling
Roberta KiffinAna Maria Cuervo
The International Journal of Biochemistry & Cell Biology
Alfred J Meijer, Patrice Codogno
© 2021 Meta ULC. All rights reserved