Autophosphorylation of αCaMKII affects social interactions in mice

Genes, Brain, and Behavior
Z HardaKasia Radwanska

Abstract

The α-Ca2+ /calmodulin-dependent protein kinase II (αCaMKII), a key regulator of the glutamatergic synapse, has been implicated in many psychiatric disorders characterized by social impairments. Here we tested whether autophosphorylation of αCaMKII at threonine 286, which prolongs the activity of the enzyme, affects social behaviors in mice. We observed that autophosphorylation-deficient (αCaMKII-T286A) mutant female mice showed abnormal social behaviors characterized by decreased social preference and interest in conspecifics of the same sex, as compared to their wild-type littermates. Moreover, we developed a mathematical approach to analyze social interactions in group-housed mice in the automated IntelliCages. Using this approach we observed that αCaMKII-T286A mutants show decreased levels of social interactions in a social group, as compared with WT mice. WT mice increased the frequency of close social interactions when learning about the location of the food reward. This phenomenon was absent in the mutants. Overall, our data indicates that autophosphorylation of αCaMKII affects social interactions.

References

May 8, 2002·Nature Reviews. Neuroscience·J LismanH Cline
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Aug 26, 2003·Nature Neuroscience·Ryohei YasudaKarel Svoboda
Mar 12, 2005·Nature Reviews. Genetics·Gene E RobinsonCharles W Whitfield
Mar 22, 2005·Nature Neuroscience·Elaine E IrvineK Peter Giese
Apr 25, 2006·The European Journal of Neuroscience·Masuo OhnoJohn F Disterhoft
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
May 26, 2011·Journal of Abnormal Child Psychology·Xue-Qiu JianJerald E Mullersman
Sep 10, 2011·Neuropharmacology·Alanna C EastonCathy Fernandes
Feb 16, 2012·Nature Reviews. Neuroscience·John LismanSridhar Raghavachari
Jul 25, 2012·Molecular Psychiatry·A C EastonG Schumann
Mar 6, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alanna C EastonMarcella Rietschel
Jan 28, 2014·Nature·Shaun M PurcellPamela Sklar
Aug 5, 2014·Trends in Neurosciences·A J Robison
Oct 8, 2014·Translational Psychiatry·A C EastonC P Müller
Dec 18, 2015·Trends in Pharmacological Sciences·Christian P MüllerK Peter Giese
Jan 29, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R StephensonRoger J Colbran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.