PMID: 46180Feb 1, 1975

Autoradiographic and fluorescent staining studies of bone marrow chromosomes from a patient with acute granulocytic leukemia

Cancer
T Sofuni, H Okada

Abstract

Results of cytogenetic studies of a patient with acute granulocytic leukemia are described. The modal number of chromosomes in cells from bone marrow samples was 43; the karyotype was characterized by missing chromosomes in groups B, C, and E. According to successive studies of the same metaphases by fluorescent staining and autoradiographic techniques, the labeling pattern of chromosomes in leukemic cells was generally similar to those observed in normal cultured leukocytes, whereas the fluorescent pattern of leukemic chromosomes was rather indistinct, and the bright fluorescent pattern of the Y chromosome was not apparent.

References

Oct 1, 1975·CRC Critical Reviews in Clinical Laboratory Sciences·L F Meisner

Citations

Jan 1, 1970·Advances in Human Genetics·O J Miller
Oct 1, 1970·Experimental Cell Research·T CasperssonC Johansson
Jul 1, 1961·Stain Technology·D H CARR, J E WALKER
Jan 1, 1963·Cytogenetics·W SCHMID
Jan 1, 1964·The Journal of Cell Biology·J GERMAN
Feb 28, 1964·Annals of the New York Academy of Sciences·A A SANDBERGL H CROSSWHITE

Related Concepts

Y Chromosome
Bone Marrow
Sex Chromosomes
White Blood Cell Count Procedure
Acute Disease
Metaphase
Hairy Cell Leukemia
Leukemia, Monocytic, Chronic
Fluorescent stain
Autosome Abnormalities

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