Autoradiographic distribution of cerebral blood flow increases elicited by stimulation of the nucleus basalis magnocellularis in the unanesthetized rat

Brain Research
E VaucherP Lacombe

Abstract

The nucleus basalis magnocellularis (NBM) of the rat, equivalent of Meynert's nucleus in the primate, is the origin of the main cholinergic innervation of the cerebral cortex. Stimulation of this area has been previously shown to induced marked, cholinergically mediated, blood flow increases in the frontal and parietal cortices. However, the complete distribution of the cerebrovascular effects of NBM stimulation within the whole brain has not been determined. In the present study, we used the [14C]iodoantipyrine autoradiographic method to measure local cerebral blood flow (CBF) in the unanesthetized rat, chronically implanted with a stimulation electrode. We performed unilateral electrical stimulation of the NBM in order to compare both the interhemispheric differences in blood flow and the differences with a group of sham-stimulated rats. Considerable blood flow increases were found in most neocortical areas, exceeding 400% in the frontal area, compared to the control group. Marked responses also appeared in discrete subcortical regions such as the zona incerta, some thalamic nuclei and structures of the extrapyramidal system. These responses were mostly ipsilateral to the stimulation. The significance and the distribution of ...Continue Reading

References

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Citations

Oct 27, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ian R MacdonaldSultan Darvesh
Mar 23, 2011·The Journal of Physiological Sciences : JPS·Harumi HottaNaoki Maruyama
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Jan 29, 2011·Acta Physiologica·C Lecrux, E Hamel
Aug 31, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Lecrux, E Hamel
Jun 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E VaucherP Lacombe
May 20, 2019·Journal of Alzheimer's Disease : JAD·Philippos KoulousakisThibaut Sesia
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G MehlhornR Schliebs

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