PMID: 9550140Apr 29, 1998Paper

Autoradiographic localisation of [3H]-SCH23390 and [3H]-spiperone binding sites in honey bee brain

The Journal of Comparative Neurology
I C KokayA R Mercer

Abstract

In the brain of the honey bee, dopamine receptors have been identified by using the vertebrate D1 dopamine antagonist [3H]-SCH23390 and the vertebrate D2 dopamine antagonist [3H]-spiperone. This study uses light microscope autoradiography to investigate the anatomical distributions of the binding sites labelled by [3H]-SCH23390 and [3H]-spiperone in tissue sections cut at three depths from the anterior surface of the brain. The binding of these radioligands differed significantly, in both density and distribution. Specific binding of [3H]-SCH23390, defined by using 5 x 10(-6) M cis-(Z)-flupentixol, was densest in regions of somata, such as the deutocerebral somatal rind, the somatal layer beneath the calyces of the mushroom bodies and the ventral protocerebral somatal group. High levels of [3H]-SCH23390 binding were also measured in the lateral protocerebrum. [3H]-Spiperone binding site density estimates were consistently lower than those of [3H]-SCH23390. Specific binding of [3H]-spiperone, determined by subtracting binding in the presence of 10(-4) M domperidone from the total binding, was highest in the alpha lobes, beta lobes, and calyces of the mushroom body neuropil. Relatively high binding was also measured in the centra...Continue Reading

References

Jul 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·D J TaylorA R Mercer
Jul 15, 1992·The Journal of Comparative Neurology·B Wendt, U Homberg
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Jan 8, 1996·Brain Research·I C Kokay, A R Mercer
Feb 12, 1996·The Journal of Comparative Neurology·A P WinningtonA R Mercer

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Citations

Oct 26, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Elizabeth CarringtonAlison R Mercer
Nov 12, 2005·Journal of Neurophysiology·Christopher G Perk, Alison R Mercer

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