PMID: 9655619Jul 9, 1998Paper

Autoradiographic localisation of muscarinic cholinergic receptor subtypes in human placenta

Neuroscience Letters
S K TayebatiF Amenta

Abstract

The localisation of M1-M4 muscarinic cholinergic receptor subtypes was investigated in sections of normal human term placenta by light microscope autoradiography. Muscarinic cholinergic receptor subtypes were found almost exclusively in syncytiotrophoblast. Neither other cellular components of placenta, nor blood vessels were labelled. Quantitative analysis of the density of silver grains developed in sections incubated with the different protocols for labelling M1-M4 receptor subtypes, revealed that syncytiotrophoblast expresses all subtypes of muscarinic cholinergic receptor investigated. A higher density of binding sites was found in the apical than in the basal portion of syncytiotrophoblast. The demonstration of muscarinic cholinergic receptors in syncytiotrophoblast suggests that a cholinergic system may have a role in regulating transport of compounds from maternal to foetal interface.

References

Sep 1, 1988·Clinical and Experimental Pharmacology & Physiology·S P BrenneckeA L Boura
Mar 15, 1972·Biochemical Pharmacology·B V Sastry, G I Henderson
Oct 1, 1971·The Tohoku Journal of Experimental Medicine·T FujiyamaK Noda
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J WhartonK M Taylor
Jan 17, 1997·Neuroscience Letters·S K TayebatiF Amenta

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Citations

May 12, 2006·Cell Communication and Signaling : CCS·Md Badiul BhuiyanMichael E Fant
Jul 25, 2008·Human & Experimental Toxicology·B González-GarcíaB Sánchez-Ramírez
May 20, 1999·Journal of Child Neurology·N SakuragawaK Kawashima

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