Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys

Brain Research
Baptiste A FaucheuxEtienne C Hirsch

Abstract

Degeneration of the nigro-striatal dopaminergic neurons occurring in Parkinson's disease is associated with an increase in iron concentrations in the substantia nigra. As this metal catalyzes the production of free radicals, and oxidative stress may participate in the cascade of events ending in cell death, this increase in iron content may be involved in dopaminergic neuronal death. The localization and number of receptors for transferrin were investigated postmortem by quantitative autoradiography of iodinated-ferrotransferrin binding in the basal ganglia from controls, parkinsonian patients and MPTP-lesioned monkeys. In human controls, specific [125i] ferrotransferrin binding-site density was highest in the putamen and the caudate nucleus, and lowest in the globus pallidus. In parkinsonian patients, it was increased in the putamen and caudate nucleus, while in MPTP-intoxicated monkeys, there was a tendency for levels to decrease in these two regions. An inverse relationship between binding density and iron content reported in the studied regions supports the assumption of a possible capture of iron at the level of dopaminergic terminals and, in parkinsonian patients, on other cellular elements as well. These results suggest ...Continue Reading

References

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Citations

Mar 15, 2001·Parkinsonism & Related Disorders·A FredrikssonT Archer
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·B A FaucheuxY Agid
Mar 12, 2004·Neurobiology of Aging·Makoto SohmiyaKoichi Okamoto
Feb 15, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Benjamin Wolozin, Natalie Golts
May 26, 2007·Journal of Neuroscience Research·Linyang SongHyman M Schipper
Apr 4, 2016·Molecular Neurobiology·Hong JiangJunxia Xie
Mar 19, 2019·Frontiers in Neuroscience·Alain NdayisabaGregor K Wenning
Aug 14, 2020·Biochemistry·Ankur A GholkarJorge Z Torres

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