PMID: 3026576Nov 1, 1986

Autoradiographic localization of beta-adrenergic receptors in the rabbit pituitary

Brain Research Bulletin
S SchimchowitschG Pelletier

Abstract

The localization and characterization of beta-adrenergic receptors in the rabbit pituitary have been studied using [125I]cyanopindolol as a specific ligand. Slide-mounted frozen sections were used for the autoradiographic localization and characterization of beta-adrenergic receptors. The displacement curves obtained from optical density of radioautograms or counting of scraped off sections demonstrated that beta-adrenergic receptors were mostly of the beta 2-subtype and highly concentrated in the intermediate lobe. Low concentrations of beta 2-adrenergic receptors were also found to be uniformly distributed in the anterior and posterior lobes. These results suggest that epinephrine and/or norepinephrine might play a physiological role in the regulation of the secretion of not only the intermediate lobe but also the anterior and posterior lobes of the rabbit pituitary.

References

Nov 1, 1988·Molecular and Cellular Endocrinology·M Tolszczuk, G Pelletier
Jan 1, 1999·Nutritional Neuroscience·S Vanhatalo, S Soinila

Citations

May 1, 1976·Journal of Medicinal Chemistry·D L TempleL E Allen
Nov 1, 1973·The Journal of Endocrinology·A Howe
Jan 1, 1970·Acta Endocrinologica. Supplementum·D Rodbard, J E Lewald
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E MezeyJ Axelrod

Related Concepts

Establishment and Maintenance of Localization
Visken
Pituitary Diseases
Middle Lobe Syndrome
Process of Secretion
Chinchilla Rabbits
Scrapings (Specimen)
Epinephrine Measurement
Adrenergic Receptor
Norepinephrine

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