Sep 1, 1989

Autoradiographic mapping of galanin receptors in the monkey brain

Journal of Chemical Neuroanatomy
C KöhlerE Norheim

Abstract

The distribution of specific binding sites for the peptide galanin was studied in the monkey brain by using 125I-galanin and the method of quantitative in vitro autoradiography. The binding to tissue sections was found to be rapid, reversible and saturable with a calculated Bmax of around 13 fmol mg-1 tissue in cortical regions and a KD ranging between 0.39 and 0.22 nM in different brain regions. Specifically bound 125I-galanin was detected in a number of brain regions throughout the rostrocaudal axis of the monkey brain. More specifically, the majority of the 125I-galanin binding sites were present in the basal forebrain (e.g. olfactory tubercle, lateral septal nuclei, nucleus accumbens, substantia innominata and the basal nucleus of Meynert), the amygdala (e.g. the lateral, medial accessory and central nuclei), the amygdala-hippocampal area, hypothalamus (e.g. the anterior hypothalamic area, the ventro-medial hypothalamus and the zona incerta), as well as in certain brain stem cell groups such as the substantia nigra (pars compacta), locus coeruleus, central grey substance, parabrachial nucleus, sensory and motor nuclei of the trigeminal nerve and the dorsal vagal complex. In the neocortex, highest binding density occurred in...Continue Reading

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Mentioned in this Paper

Mammillary Body Structure
Pars Compacta
Substantia Innominata
Structure of Reticular Formation of Spinal Cord
Genus fimbria
Central Gray Substance
Receptors, Gastrointestinal Hormone
Immunoreactivity
Cerebellar Nuclei
Tract

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