Autoradiographic study on the distribution of thymus-derived and thymus-independent lymphocytes in the spleen of Xenopus laevis

Developmental and Comparative Immunology
N Obara

Abstract

Non-thymectomized and early-thymectomized Xenopus laevis were injected with 3H-thymidine, and labelled lymphocytes from thymus, spleen, and peripheral blood were transferred to histocompatible recipients to study their distribution by autoradiography. An extremely high proportion of labelled thymocytes was localized in the splenic red pulp of both non-thymectomized and thymectomized recipients after transfer. Labelled splenic lymphocytes were localized in a significantly higher density in the splenic white- than red pulp, particularly 24 hr after cell transfer. This preference of labelled lymphocytes in the white pulp was more evident when early-thymectomized toads were used as lymphocyte donors. These results strongly suggest that in Xenopus, thymus-independent lymphocytes preferentially localize in the splenic white pulp, and thymus-derived lymphocytes possibly in the red pulp.

References

Jan 1, 1976·Comparative Biochemistry and Physiology. A, Comparative Physiology·R D Jurd, G T Stevenson
Oct 1, 1977·Transplantation·J D HortonJ J Rimmer
Oct 1, 1978·Developmental and Comparative Immunology·S Nagata, S Tochinai
Feb 1, 1978·Developmental and Comparative Immunology·C Katagiri
Jun 1, 1976·European Journal of Immunology·M H CollieM J Manning
Jan 1, 1973·The Journal of Experimental Zoology·R J Turner, M J Manning
May 1, 1974·European Journal of Immunology·R J Turner, M J Manning
Aug 1, 1974·Journal of Morphology·J D Horton, M J Manning
Jan 1, 1966·The Journal of Experimental Medicine·D V ParrottJ East
Aug 1, 1962·The Journal of Experimental Medicine·B H WAKSMANB D JANKOVIC

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