PMID: 9437715Jan 1, 1997Paper

Autoradiographic visualization of the receptor subclasses for vasoactive intestinal polypeptide (VIP) in rat brain

Peptides
P VertongenP Robberecht

Abstract

Vasoactive Intestinal Polypeptide (VIP) exerts its biological effects through interaction with two high affinity receptors named the VIP1- and the VIP2 receptors. Their messenger RNAs have been mapped in rat brain by in situ hybridization. A cyclic peptide (RO 25-1553) and a secretion analogue ([R16]chicken secretin) were identified as selective agonist peptides for the VIP2- and VIP1 receptors, respectively. The iodinated peptides retained the high affinity and selectivity of the unlabelled peptides and were used for the mapping of each receptor subclass in rat brain. VIP1 receptors were present in the cerebral cortex, the piriform cortex, the claustrum, the caudate-putamen, the dentate gyrus, the lateral amygdaloïd nucleus, the anteroventral thalamic nucleus, the rhomboïd nucleus, the supraoptic nucleus and the choroïd plexus. VIP2 receptors were present in the cerebral cortex, the claustrum, the caudate-putamen, the nucleus accumbens, the lateral septal nuclei, the bed nucleus of the stria terminalis, the basolateral amygdaloïd nucleus, the Ammon's horn, the thalamic nuclei except some centromedial nuclei, the medial habenula, the suprachiasmatic nucleus, the periventricular nucleus, the mammilary nucleus, the superior colli...Continue Reading

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Citations

Sep 1, 1999·Microscopy Research and Technique·B Cozzi
Jan 3, 2001·Microscopy Research and Technique·A Chodobski, J Szmydynger-Chodobska
Nov 14, 2013·Neuropeptides·Sanbing ShenDavid A Collier
Sep 3, 1998·European Journal of Pharmacology·P GourletP Robberecht
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 28, 1999·Journal of Chemical Neuroanatomy·J M BurgunderT Lauterburg
Mar 6, 2002·The European Journal of Neuroscience·Henriette S NielsenJan Fahrenkrug
Feb 3, 1999·Annals of the New York Academy of Sciences·P Robberecht, M Waelbroeck
Feb 3, 1999·Annals of the New York Academy of Sciences·P GourletP Robberecht
Jul 12, 2008·BMC Neuroscience·Dipesh ChaudhuryChristopher S Colwell
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShenA J Harmar
Aug 31, 2002·Journal of Molecular Recognition : JMR·Sarah BhargavaRudolf Volkmer-Engert
Nov 15, 2011·Journal of Immunological Methods·Rebecca J HermannGlenn P Dorsam
Sep 23, 2008·Neuropharmacology·Sang-Hun Lee, Charles L Cox
May 2, 2015·Polish Journal of Veterinary Sciences·R Bukowski, K Wąsowicz
Nov 18, 2003·Endocrinology·Anthony J HarmarJean Claude Reubi
May 20, 2020·Frontiers in Cellular Neuroscience·Gregory C JohnsonSayamwong E Hammack

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